The average train between Santander and Guadalajara takes 9h 40m and the fastest train takes 6h 24m. The train service runs several times per day from Santander to Guadalajara. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Santander and Guadalajara. The earliest departure is at 6:48 AM in the morning, and the last departure from Santander is at 7:00 PM which arrives into Guadalajara at 9:20 AM. All services require a transfer, and take on average 9h 40m. The schedules shown below are for the next available departures.

9h 35m • 1 change

6h 24m • 1 change
Arrives next day

14h 20m • 1 change

9h 35m • 1 change

6h 24m • 1 change
Arrives next day

14h 20m • 1 change

9h 35m • 1 change

6h 24m • 1 change
Arrives next day

14h 20m • 1 change

9h 35m • 1 change

6h 24m • 1 change
Arrives next day

14h 20m • 1 change
Want to know about travelling from Santander to Guadalajara? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Santander to Guadalajara. However, there are services departing from Santander station and arriving at Guadalajara station via Madrid Chamartín. The journey, including transfers, takes approximately 9h 40m.
Santander to Guadalajara train services, operated by Renfe Viajeros, depart from Santander station.
Santander to Guadalajara train services, operated by Renfe Viajeros, arrive at Guadalajara station.
Book your Santander to Guadalajara train tickets online with Renfe Viajeros.
The distance between Santander and Guadalajara is 319.8 km. The road distance is 505 km.
You can take a train from Santander to Guadalajara via Madrid Chamartín in around 5h 35m.