The average train between Santander and Salamanca takes 4h 38m and the fastest train takes 4h 19m. The train service runs several times per day from Santander to Salamanca. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Santander and Salamanca. The earliest departure is at 6:48 AM in the morning, and the last departure from Santander is at 6:45 PM which arrives into Salamanca at 11:11 PM. All services require a transfer, and take on average 4h 38m. The schedules shown below are for the next available departures.

4h 19m • 1 change

4h 33m • 1 change

4h 31m • 1 change

4h 45m • 1 change

4h 51m • 1 change

4h 19m • 1 change

4h 33m • 1 change

4h 31m • 1 change

4h 51m • 1 change

4h 19m • 1 change

4h 33m • 1 change

4h 31m • 1 change

4h 51m • 1 change

4h 19m • 1 change

4h 33m • 1 change

4h 31m • 1 change

4h 51m • 1 change

4h 19m • 1 change

4h 33m • 1 change

4h 31m • 1 change

4h 51m • 1 change

4h 19m • 1 change

4h 33m • 1 change

4h 31m • 1 change
Want to know about travelling from Santander to Salamanca? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Santander to Salamanca. However, there are services departing from Santander station and arriving at Salamanca station via Madrid Chamartín. The journey, including transfers, takes approximately 4h 38m.
Santander to Salamanca train services, operated by Renfe Viajeros, depart from Santander station.
Santander to Salamanca train services, operated by Renfe Viajeros, arrive at Madrid Chamartín station.
Book your Santander to Salamanca train tickets online with Renfe Viajeros and Renfe Cercanias.
The distance between Santander and Salamanca is 337.6 km. The road distance is 446 km.
Renfe Viajeros operates a train from Santander to Madrid Chamartín every 4 hours. Tickets cost €55–85 and the journey takes 4h 14m.