The average train between Santarém and Ayamonte takes 5h 36m and the fastest train takes 5h 22m. The train service runs several times per day from Santarém to Ayamonte. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Santarém and Ayamonte. The earliest departure is at 7:07 AM in the morning, and the last departure from Santarém is at 5:40 PM which arrives into Ayamonte at 11:07 PM. All services require a transfer at Lisboa Oriente and take an average of 5h 36m. The schedules shown below are for the next available departures.


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5h 36m • 2 changes
Want to know about travelling from Santarém to Ayamonte? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Santarém to Ayamonte. However, there are services departing from Santarém station and arriving at Ayamonte station via Lisboa Oriente. The journey, including transfers, takes approximately 5h 36m.
Santarém to Ayamonte train services, operated by Comboios de Portugal, depart from Santarem station.
Santarém to Ayamonte train services, operated by Comboios de Portugal, arrive at Vila Real De Santo Antonio station.
Book your Santarém to Ayamonte train tickets online with Comboios de Portugal.
The distance between Santarém and Ayamonte is 250.7 km. The road distance is 426 km.
You can take a train from Santarem to Vila Real De Santo Antonio via Lisboa Oriente and Faro in around 6h 24m.