Santo Spirito to Piazza del Duomo Trains

Santo Spirito to Piazza del Duomo trains

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Trip Overview

The average train between Santo Spirito and Piazza del Duomo takes 2h 16m and the fastest train takes 2h 1m. There is a train service every few hours from Santo Spirito to Piazza del Duomo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2h 16m
Duration: 303 km
Distance: €68
Average price: Hourly
Frequency

Train

best

Take the train from Firenze S.M.N. to Milano Rogoredotrain Fr

2h 17m

€33–115

Santo Spirito to Piazza del Duomo train times

Trains run hourly between Santo Spirito and Piazza del Duomo. The earliest departure is at 6:55 AM in the morning, and the last departure from Santo Spirito is at 9:55 PM which arrives into Piazza del Duomo at 12:15 AM. All services require a transfer at Firenze S.M.N. and take an average of 2h 16m. The schedules shown below are for the next available departures.

Departing Tuesday, August 18, 2026

3:55 PM → 6:06 PM
2h 11m • 1 change
4:55 PM → 7:13 PM
2h 18m • 1 change
5:55 PM → 8:10 PM
2h 15m • 1 change
6:55 PM → 9:11 PM
2h 16m • 1 change
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Departing Wednesday, August 19, 2026

6:55 AM → 9:04 AM
2h 9m • 1 change
7:10 AM → 9:11 AM
2h 1m • 1 change
9:10 AM → 12:06 PM
2h 56m • 1 change
9:55 AM → 12:13 PM
2h 18m • 1 change
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Departing Thursday, August 20, 2026

6:55 AM → 9:04 AM
2h 9m • 1 change
7:10 AM → 9:11 AM
2h 1m • 1 change
9:10 AM → 12:06 PM
2h 56m • 1 change
9:55 AM → 12:13 PM
2h 18m • 1 change
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Departing Friday, August 21, 2026

7:10 AM → 9:11 AM
2h 1m • 1 change
9:10 AM → 12:06 PM
2h 56m • 1 change
9:55 AM → 12:13 PM
2h 18m • 1 change
10:55 AM → 1:09 PM
2h 14m • 1 change
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Frequently asked questions

Want to know about travelling from Santo Spirito to Piazza del Duomo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

What companies run services between Santo Spirito, Tuscany, Italy and Piazza del Duomo, Lombardy, Italy?

Trenitalia Frecce operates a train from Firenze S.M.N. to Milano Rogoredo every 30 minutes. Tickets cost €40–90 and the journey takes 1h 44m. Three other operators also service this route.

Operators