The train between Segrate and Domodossola takes 2h 1m. The train service runs several times per day from Segrate to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Segrate and Domodossola. The earliest departure is at 6:42 AM in the morning, and the last departure from Segrate is at 6:42 PM which arrives into Domodossola at 8:43 PM. All services require a transfer at Milano Repubblica and take an average of 2h 1m. The schedules shown below are for the next available departures.

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Want to know about travelling from Segrate to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Segrate to Domodossola. However, there are services departing from Segrate station and arriving at Domodossola station via Domodossola. The journey, including transfers, takes approximately 2h 1m.
Segrate to Domodossola train services, operated by Trenord, depart from Milano Centrale station.
Segrate to Domodossola train services, operated by Trenord, arrive at Domodossola station.
Book your Segrate to Domodossola train tickets online with Trenord and Trenitalia EuroCity.
The distance between Segrate and Domodossola is 104.4 km. The road distance is 132 km.
Trenitalia EuroCity operates a train from Milano Centrale to Domodossola every 4 hours. Tickets cost €30–75 and the journey takes 1h 33m.