The average train between Seregno and Rome takes 4h 15m and the fastest train takes 3h 26m. There is a train service every few hours from Seregno to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Seregno and Rome. The earliest departure is at 4:59 AM at night, and the last departure from Seregno is at 9:59 PM which arrives into Rome at 8:40 AM. All services require a transfer, and take on average 4h 15m. The schedules shown below are for the next available departures.

3h 40m • 1 change

3h 26m • 1 change
Arrives next day

10h 41m • 1 change

4h 12m • 1 change

3h 45m • 1 change

3h 41m • 1 change

3h 42m • 1 change

4h 12m • 1 change

3h 45m • 1 change

3h 41m • 1 change

3h 42m • 1 change

4h 12m • 1 change

3h 45m • 1 change

3h 41m • 1 change

3h 42m • 1 change
Want to know about travelling from Seregno to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Seregno to Rome. However, there are services departing from Seregno station and arriving at Rome station via Roma Termini. The journey, including transfers, takes approximately 4h 15m.
Seregno to Rome train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Milano Centrale station.
Seregno to Rome train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Roma Termini station.
Book your Seregno to Rome train tickets online with Swiss Federal Railways (SBB CFF FFS) and Trenitalia Frecce.
The distance between Seregno and Rome is 493.6 km. The road distance is 583 km.
Trenitalia Frecce operates a train from Milano Centrale to Roma Termini every 20 minutes. Tickets cost €80–170 and the journey takes 3h 4m. ItaloTreno also services this route once daily.