The average train between Seregno and Rome takes 4h 21m and the fastest train takes 4h 1m. There is a train service every few hours from Seregno to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Seregno and Rome. The earliest departure is at 4:59 AM at night, and the last departure from Seregno is at 6:59 PM which arrives into Rome at 11:24 PM. All services require a transfer, and take on average 4h 21m. The schedules shown below are for the next available departures.

4h 26m • 1 change

4h 36m • 1 change

4h 1m • 1 change

4h 20m • 1 change

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4h 1m • 1 change

4h 20m • 1 change

4h 26m • 1 change

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4h 1m • 1 change

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4h 26m • 1 change

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4h 1m • 1 change

4h 20m • 1 change
Want to know about travelling from Seregno to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Seregno to Rome. However, there are services departing from Seregno station and arriving at Rome station via Roma Termini. The journey, including transfers, takes approximately 4h 21m.
Seregno to Rome train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Milano Centrale station.
Seregno to Rome train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Roma Termini station.
Book your Seregno to Rome train tickets online with Swiss Federal Railways (SBB CFF FFS) and ItaloTreno.
The distance between Seregno and Rome is 493.6 km. The road distance is 602 km.
ItaloTreno operates a train from Milano Centrale to Roma Termini every 30 minutes. Tickets cost €75–150 and the journey takes 3h 5m.