The average train between Seregno and Rome takes 5h 40m and the fastest train takes 4h 20m. There is a train service every few hours from Seregno to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Seregno and Rome. The earliest departure is at 4:59 AM at night, and the last departure from Seregno is at 9:59 PM which arrives into Rome at 9:25 AM. All services require a transfer, and take on average 5h 40m. The schedules shown below are for the next available departures.

4h 20m • 1 change

5h 20m • 1 change

5h 15m • 1 change

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5h 16m • 1 change

5h 26m • 1 change

5h 11m • 1 change

5h 16m • 1 change

5h 16m • 1 change

5h 26m • 1 change

5h 11m • 1 change

5h 16m • 1 change

5h 16m • 1 change

5h 26m • 1 change

5h 11m • 1 change

5h 16m • 1 change
Want to know about travelling from Seregno to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Seregno to Rome. However, there are services departing from Seregno station and arriving at Rome station via Roma Termini. The journey, including transfers, takes approximately 5h 40m.
Seregno to Rome train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Milano Centrale station.
Seregno to Rome train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Roma Termini station.
Book your Seregno to Rome train tickets online with Swiss Federal Railways (SBB CFF FFS), ItaloTreno and Trenitalia Frecce.
The distance between Seregno and Rome is 493.6 km. The road distance is 583 km.
Trenitalia Frecce operates a train from Milano Centrale to Roma Termini every 30 minutes. Tickets cost €85–170 and the journey takes 3h 4m. ItaloTreno also services this route once daily.