The average train between Sesto Calende and Rome takes 5h 17m and the fastest train takes 4h. The train service runs several times per day from Sesto Calende to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Sesto Calende and Rome. The earliest departure is at 7:19 AM in the morning, and the last departure from Sesto Calende is at 9:25 PM which arrives into Rome at 9:19 AM. All services require a transfer, and take on average 5h 17m. The schedules shown below are for the next available departures.

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Want to know about travelling from Sesto Calende to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Sesto Calende to Rome. However, there are services departing from Sesto Calende station and arriving at Rome station via Rho-Fiera Milano. The journey, including transfers, takes approximately 5h 17m.
Sesto Calende to Rome train services, operated by Trenitalia, depart from Sesto Calende station.
Sesto Calende to Rome train services, operated by Trenitalia, arrive at Roma Termini station.
Book your Sesto Calende to Rome train tickets online with Trenitalia and ItaloTreno.
The distance between Sesto Calende and Rome is 526.1 km. The road distance is 617 km.
You can take a train from Sesto Calende to Roma Termini via Milano Rogoredo in around 3h 58m.