The average train between Sesto Calende and Siena takes 5h 21m and the fastest train takes 5h 14m. The train service runs several times per day from Sesto Calende to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Sesto Calende and Siena. The earliest departure is at 7:19 AM in the morning, and the last departure from Sesto Calende is at 5:25 PM which arrives into Siena at 11:16 PM. All services require a transfer at Milano P.Garibaldi and take an average of 5h 21m. The schedules shown below are for the next available departures.


5h 19m • 2 changes

5h 14m • 2 changes

5h 15m • 2 changes

5h 15m • 2 changes

5h 19m • 2 changes

5h 14m • 2 changes

5h 15m • 2 changes

5h 15m • 2 changes

5h 19m • 2 changes

5h 14m • 2 changes

5h 15m • 2 changes

5h 15m • 2 changes

5h 19m • 2 changes

5h 14m • 2 changes

5h 15m • 2 changes

5h 15m • 2 changesWant to know about travelling from Sesto Calende to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Sesto Calende to Siena. However, there are services departing from Sesto Calende station and arriving at Siena station via Milano P.Garibaldi. The journey, including transfers, takes approximately 5h 21m.
Sesto Calende to Siena train services, operated by Trenitalia, depart from Sesto Calende station.
Sesto Calende to Siena train services, operated by Trenitalia, arrive at Siena station.
Book your Sesto Calende to Siena train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Sesto Calende and Siena is 342.4 km. The road distance is 453 km.
You can take a train from Sesto Calende to Siena via Milano P.Garibaldi and Firenze S.M.N. in around 5h 52m.