The average train between Sesto San Giovanni and Rome takes 4h 27m and the fastest train takes 3h 40m. There is a train service every few hours from Sesto San Giovanni to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Sesto San Giovanni and Rome. The earliest departure is at 12:15 AM at night, and the last departure from Sesto San Giovanni is at 7:01 PM which arrives into Rome at 11:24 PM. All services require a transfer at stazione centrale via tonale and take an average of 4h 27m. The schedules shown below are for the next available departures.

3h 47m • 1 change

4h 17m • 1 change

3h 47m • 1 change

4h 19m • 1 change

9h 8m • 1 change

3h 48m • 1 change

3h 48m • 1 change

4h 22m • 1 change

9h 8m • 1 change

3h 48m • 1 change

3h 48m • 1 change

4h 22m • 1 change

9h 8m • 1 change

3h 48m • 1 change

3h 48m • 1 change

4h 22m • 1 change
Want to know about travelling from Sesto San Giovanni to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Sesto San Giovanni to Rome. However, there are services departing from Sesto San Giovanni station and arriving at Rome station via Roma Termini. The journey, including transfers, takes approximately 4h 27m.
Sesto San Giovanni to Rome train services, operated by ATM, depart from Milano Centrale station.
Sesto San Giovanni to Rome train services, operated by ATM, arrive at Roma Termini station.
Book your Sesto San Giovanni to Rome train tickets online with ATM and ItaloTreno.
The distance between Sesto San Giovanni and Rome is 482 km. The road distance is 567 km.
Trenitalia Frecce operates a train from Milano Centrale to Roma Termini every 20 minutes. Tickets cost €80–170 and the journey takes 3h 4m. ItaloTreno also services this route once daily.