The average train between Siena Station and Milan takes 5h 24m and the fastest train takes 3h 55m. There is a train service every few hours from Siena Station to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Siena Station and Milan. The earliest departure is at 6:25 AM in the morning, and the last departure from Siena Station is at 9:40 PM which arrives into Milan at 9:25 AM. All services require a transfer, and take on average 5h 24m. The schedules shown below are for the next available departures.

5h 2m • 1 change

5h 2m • 1 change

5h 7m • 1 change

5h 7m • 1 change

3h 55m • 1 change

4h 28m • 1 change

4h 37m • 1 change

5h 7m • 1 change

3h 55m • 1 change

4h 28m • 1 change

4h 37m • 1 change

5h 7m • 1 change

3h 55m • 1 change

4h 28m • 1 change

4h 37m • 1 change

5h 7m • 1 change
Want to know about travelling from Siena Station to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Siena Station to Milan. However, there are services departing from Siena Station station and arriving at Milan station via Firenze S.M.N.. The journey, including transfers, takes approximately 5h 24m.
Siena Station to Milan train services, operated by Trenitalia, depart from Siena station.
Siena Station to Milan train services, operated by Trenitalia, arrive at Milano Centrale station.
Book your Siena Station to Milan train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Siena Station and Milan is 291.5 km. The road distance is 397 km.
You can take a train from Siena to Milano Centrale via Firenze S.M.N. in around 3h 47m.