The average train between Siena and Isernia takes 9h 29m and the fastest train takes 6h 5m. The train service runs several times per day from Siena to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Siena and Isernia. The earliest departure is at 9:18 AM in the morning, and the last departure from Siena is at 9:40 PM which arrives into Isernia at 11:15 AM. All services require a transfer at Firenze S.M.N. and take an average of 9h 29m. The schedules shown below are for the next available departures.
Want to know about travelling from Siena to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Siena to Isernia. However, there are services departing from Siena station and arriving at Isernia station via Firenze S.M.N.. The journey, including transfers, takes approximately 9h 29m.
Siena to Isernia train services, operated by Trenitalia, depart from Siena station.
Siena to Isernia train services, operated by Trenitalia, arrive at Isernia station.
Book your Siena to Isernia train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Siena and Isernia is 305.6 km. The road distance is 540 km.
You can take a train from Siena to Isernia via Firenze S.M.N. and Roma Termini in around 6h 26m.
