The average train between Slough and Penzance takes 5h 36m and the fastest train takes 5h 8m. The train service runs several times per day from Slough to Penzance. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Slough and Penzance. The earliest departure is at 5:47 AM in the morning, and the last departure from Slough is at 11:57 PM which arrives into Penzance at 7:54 AM. All services require a transfer, and take on average 5h 36m. The schedules shown below are for the next available departures.

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Want to know about travelling from Slough to Penzance? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Slough to Penzance. However, there are services departing from Slough station and arriving at Penzance station via Penzance. The journey, including transfers, takes approximately 5h 36m.
Slough to Penzance train services, operated by Great Western Railway (GWR), depart from Reading station.
Slough to Penzance train services, operated by Great Western Railway (GWR), arrive at Penzance station.
Book your Slough to Penzance train tickets online with Great Western Railway (GWR) and Elizabeth Line (TfL).
The distance between Slough and Penzance is 380 km. The road distance is 458 km.
Great Western Railway (GWR) operates a train from Reading to Penzance every 2 hours. Tickets cost £120–230 and the journey takes 7h 6m.