The average train between Slough and Plymouth takes 3h 33m and the fastest train takes 3h 9m. There is a train service every few hours from Slough to Plymouth. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Slough and Plymouth. The earliest departure is at 5:47 AM in the morning, and the last departure from Slough is at 11:57 PM which arrives into Plymouth at 5:10 AM. All services require a transfer, and take on average 3h 33m. The schedules shown below are for the next available departures.

3h 54m • 1 change

3h 16m • 1 change

3h 20m • 1 change

3h 9m • 1 change

3h 54m • 1 change

3h 16m • 1 change

3h 20m • 1 change

3h 9m • 1 change

3h 40m • 1 change

3h 21m • 1 change

3h 13m • 1 change

3h 24m • 1 change
Want to know about travelling from Slough to Plymouth? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Slough to Plymouth. However, there are services departing from Slough station and arriving at Plymouth station via Plymouth. The journey, including transfers, takes approximately 3h 33m.
Slough to Plymouth train services, operated by Elizabeth Line (TfL), depart from Reading station.
Slough to Plymouth train services, operated by Elizabeth Line (TfL), arrive at Plymouth station.
Book your Slough to Plymouth train tickets online with Elizabeth Line (TfL) and Great Western Railway (GWR).
The distance between Slough and Plymouth is 278.9 km. The road distance is 331 km.
Great Western Railway (GWR) operates a train from Reading to Plymouth hourly. Tickets cost £85–170 and the journey takes 2h 46m.