The average train between Southampton and Port of Holyhead takes 7h 32m and the fastest train takes 6h 33m. The train service runs several times per day from Southampton to Port of Holyhead. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Southampton and Port of Holyhead. The earliest departure is at 5:15 AM in the morning, and the last departure from Southampton is at 7:15 PM which arrives into Port of Holyhead at 8:25 AM. All services require a transfer at Stafford and take an average of 7h 32m. The schedules shown below are for the next available departures.

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Want to know about travelling from Southampton to Port of Holyhead? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Southampton to Port of Holyhead. However, there are services departing from Southampton station and arriving at Port of Holyhead station via Stafford. The journey, including transfers, takes approximately 7h 32m.
Southampton to Port of Holyhead train services, operated by Cross Country, depart from Southampton Central station.
Southampton to Port of Holyhead train services, operated by Cross Country, arrive at Holyhead station.
Book your Southampton to Port of Holyhead train tickets online with Cross Country and Avanti West Coast.
The distance between Southampton and Port of Holyhead is 346.4 km. The road distance is 486 km.
You can take a train from Southampton Central to Port of Holyhead via Stafford and Holyhead in around 6h 51m.