The average train between Southampton and Slough takes 1h 22m and the fastest train takes 1h 14m. There is a train service every few hours from Southampton to Slough. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Southampton and Slough. The earliest departure is at 5:15 AM in the morning, and the last departure from Southampton is at 8:15 PM which arrives into Slough at 9:52 PM. All services require a transfer, and take on average 1h 22m. The schedules shown below are for the next available departures.

1h 21m • 1 change

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1h 29m • 1 change

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1h 29m • 1 change
Want to know about travelling from Southampton to Slough? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Southampton to Slough. However, there are services departing from Southampton station and arriving at Slough station via Reading. The journey, including transfers, takes approximately 1h 22m.
Southampton to Slough train services, operated by Cross Country, depart from Southampton Central station.
Southampton to Slough train services, operated by Cross Country, arrive at Slough station.
Book your Southampton to Slough train tickets online with Cross Country, Elizabeth Line (TfL) and Great Western Railway (GWR).
The distance between Southampton and Slough is 87.8 km. The road distance is 103 km.
You can take a train from Southampton Central to Slough via Reading in around 1h 18m.