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Spoleto to Isernia trains

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Trip Overview

The average train between Spoleto and Isernia takes 5h 55m and the fastest train takes 3h 39m. The train service runs several times per day from Spoleto to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 55m
Duration
310 km
Distance
€43
Average price
5 times a day
Frequency

Train (Trenitalia)

best
  1. Take the train from Spoleto to Roma Terminitrain train 4153 / ...
  2. Take the train from Roma Termini to Iserniatrain train Re
4h 49m
€35–64

Spoleto to Isernia train times

Trains run 5 times a day between Spoleto and Isernia. The earliest departure is at 7:17 AM in the morning, and the last departure from Spoleto is at 10:05 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 5h 55m. The schedules shown below are for the next available departures.

Departing Monday, October 12, 2026

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    Arrives next day

    TrenitaliaTrenitalia10h 22m • 1 change

Departing Tuesday, October 13, 2026

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    Trenitalia IntercityTrenitalia3h 39m • 1 change

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    Trenitalia FrecceTrenitalia5h 45m • 1 change

  •  → 

    TrenitaliaTrenitalia5h 16m • 1 change

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    TrenitaliaTrenitalia5h 21m • 1 change
  • Show more

Departing Wednesday, October 14, 2026

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    Trenitalia IntercityTrenitalia3h 39m • 1 change

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    Trenitalia FrecceTrenitalia5h 45m • 1 change

  •  → 

    TrenitaliaTrenitalia5h 16m • 1 change

  •  → 

    TrenitaliaTrenitalia5h 21m • 1 change
  • Show more

Departing Thursday, October 15, 2026

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    Trenitalia IntercityTrenitalia3h 39m • 1 change

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    Trenitalia FrecceTrenitalia5h 45m • 1 change

  •  → 

    TrenitaliaTrenitalia5h 16m • 1 change

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    TrenitaliaTrenitalia5h 21m • 1 change
  • Show more

Departing Friday, October 16, 2026

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    Trenitalia IntercityTrenitalia3h 39m • 1 change

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    Trenitalia FrecceTrenitalia5h 45m • 1 change

  •  → 

    TrenitaliaTrenitalia5h 16m • 1 change

  •  → 

    TrenitaliaTrenitalia5h 21m • 1 change
  • Show more

Departing Saturday, October 17, 2026

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    Trenitalia IntercityTrenitalia3h 39m • 1 change

  •  → 

    Trenitalia FrecceTrenitalia5h 45m • 1 change

  •  → 

    TrenitaliaTrenitalia5h 16m • 1 change

  •  → 

    TrenitaliaTrenitalia5h 21m • 1 change
  • Show more

Departing Sunday, October 18, 2026

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    TrenitaliaTrenitalia3h 58m • 1 change

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    TrenitaliaTrenitalia4h 7m • 1 change

  •  → 

    TrenitaliaTrenitalia4h 55m • 1 change

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    TrenitaliaTrenitalia6h 9m • 1 change

Frequently asked questions

Want to know about travelling from Spoleto to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Spoleto to Isernia.ExpandLaunch map view
  • Distance: 310.1 km
  • Duration: 5h 55m

What companies run services between Spoleto, Italy and Isernia, Italy?

You can take a train from Spoleto to Isernia via Roma Termini in around 4h 49m.

Operators