Rome2Rio

St. Louis to Florence trains

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Trip Overview

The train between St. Louis and Florence takes 42h. The train runs, on average, 6 times per week from St. Louis to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

42h
Duration
1,456 mi
Distance
$422
Average price
6 times a week
Frequency

St. Louis to Florence train times

Trains run 6 times a week between St. Louis and Florence. The earliest departure is at 8:10 AM in the morning, and the last departure from St. Louis is at 8:10 AM which arrives into Florence at 3:10 AM. All services require a transfer at Chicago Union Station and take an average of 42h. The schedules shown below are for the next available departures.

Departing Friday, October 9, 2026

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    Arrives +2 days

    AmtrakAmtrakAmtrak42h • 2 changes

Departing Saturday, October 10, 2026

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    Arrives +2 days

    AmtrakAmtrakAmtrak42h • 2 changes

Departing Sunday, October 11, 2026

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    Arrives +2 days

    AmtrakAmtrakAmtrak42h • 2 changes

Departing Monday, October 12, 2026

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    Arrives +2 days

    AmtrakAmtrakAmtrak42h • 2 changes

Departing Tuesday, October 13, 2026

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    Arrives +2 days

    AmtrakAmtrakAmtrak42h • 2 changes

Departing Wednesday, October 14, 2026

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    Arrives +2 days

    AmtrakAmtrakAmtrak42h • 2 changes

Frequently asked questions

Want to know about travelling from St. Louis to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to Florence.ExpandLaunch map view
  • Distance: 1,456 mi
  • Duration: 42h

What companies run services between St. Louis, MO, USA and Florence, SC, USA?

You can take a train from St. Louis to Florence Station via Chicago Union Station and Petersburg Amtrak Station in around 33h 4m.

Operators