The average train between Tuscany and Domodossola takes 6h 6m and the fastest train takes 4h 18m. The train service runs several times per day from Tuscany to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Tuscany and Domodossola. The earliest departure is at 12:25 PM in the afternoon, and the last departure from Tuscany is at 7:25 PM which arrives into Domodossola at 8:43 AM. All services require a transfer, and take on average 6h 6m. The schedules shown below are for the next available departures.

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4h 18m • 1 changeWant to know about travelling from Tuscany to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Tuscany to Domodossola. However, there are services departing from Tuscany station and arriving at Domodossola station via Milano Centrale. The journey, including transfers, takes approximately 6h 6m.
Tuscany to Domodossola train services, operated by ItaloTreno, depart from Firenze Santa Maria Novella station.
Tuscany to Domodossola train services, operated by ItaloTreno, arrive at Domodossola station.
Book your Tuscany to Domodossola train tickets online with ItaloTreno and Trenitalia EuroCity.
The distance between Tuscany and Domodossola is 371.1 km. The road distance is 425 km.
You can take a train from Firenze Santa Maria Novella to Domodossola via Milano Centrale in around 4h 20m.