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Tuscany to Isernia trains

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Trip Overview

The average train between Tuscany and Isernia takes 5h 20m and the fastest train takes 3h 52m. The train service runs several times per day from Tuscany to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 20m
Duration
447 km
Distance
€63
Average price
5 times a day
Frequency

Train (Trenitalia)

best
  1. Take the train from Firenze S.M.N. to Roma Terminitrain train Fr
  2. Take the train from Roma Termini to Iserniatrain train Re
4h 44m
€50–95

Tuscany to Isernia train times

Trains run 5 times a day between Tuscany and Isernia. The earliest departure is at 7:05 AM in the morning, and the last departure from Tuscany is at 10:14 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 5h 20m. The schedules shown below are for the next available departures.

Departing Monday, October 12, 2026

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    Arrives next day

    Trenitalia FrecceTrenitalia10h 13m • 1 change

Departing Tuesday, October 13, 2026

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    Trenitalia FrecceTrenitalia4h 10m • 1 change

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    Trenitalia FrecceTrenitalia4h 9m • 1 change

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    Trenitalia FrecceTrenitalia3h 52m • 1 change

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    Trenitalia FrecceTrenitalia4h 12m • 1 change
  • Show more

Departing Wednesday, October 14, 2026

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    Trenitalia FrecceTrenitalia4h 10m • 1 change

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    Trenitalia FrecceTrenitalia4h 9m • 1 change

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    Trenitalia FrecceTrenitalia3h 52m • 1 change

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    Trenitalia FrecceTrenitalia4h 12m • 1 change
  • Show more

Departing Thursday, October 15, 2026

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    Trenitalia FrecceTrenitalia4h 10m • 1 change

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    Trenitalia FrecceTrenitalia4h 9m • 1 change

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    Trenitalia FrecceTrenitalia3h 52m • 1 change

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    Trenitalia FrecceTrenitalia4h 12m • 1 change
  • Show more

Departing Friday, October 16, 2026

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    Trenitalia FrecceTrenitalia4h 10m • 1 change

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    Trenitalia FrecceTrenitalia4h 9m • 1 change

  •  → 

    Trenitalia FrecceTrenitalia3h 52m • 1 change

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    Trenitalia FrecceTrenitalia4h 12m • 1 change
  • Show more

Departing Saturday, October 17, 2026

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    Trenitalia FrecceTrenitalia4h 10m • 1 change

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    Trenitalia FrecceTrenitalia4h 9m • 1 change

  •  → 

    Trenitalia FrecceTrenitalia3h 52m • 1 change

  •  → 

    Trenitalia FrecceTrenitalia4h 12m • 1 change
  • Show more

Departing Sunday, October 18, 2026

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    Trenitalia FrecceTrenitalia4h 10m • 1 change

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    Trenitalia FrecceTrenitalia3h 52m • 1 change

  •  → 

    Trenitalia FrecceTrenitalia4h 7m • 1 change

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    Trenitalia FrecceTrenitalia4h 9m • 1 change

Frequently asked questions

Want to know about travelling from Tuscany to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Tuscany to Isernia.ExpandLaunch map view
  • Distance: 446.8 km
  • Duration: 5h 20m

What companies run services between Tuscany, Italy and Isernia, Italy?

You can take a train from Firenze S.M.N. to Isernia via Roma Termini in around 4h 44m.

Operators