The average train between Twiste and Frankfurt am Main takes 3h 4m and the fastest train takes 2h 57m. There is a train service every few hours from Twiste to Frankfurt am Main. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Twiste and Frankfurt am Main. The earliest departure is at 4:44 AM at night, and the last departure from Twiste is at 9:14 PM which arrives into Frankfurt am Main at 1:04 AM. All services require a transfer, and take on average 3h 4m. The schedules shown below are for the next available departures.

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2h 57m • 1 change

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3h 30m • 1 change

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3h 7m • 1 change

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Want to know about travelling from Twiste to Frankfurt am Main? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Twiste to Frankfurt am Main. However, there are services departing from Twiste station and arriving at Frankfurt am Main station via Kassel Bahnhof Wilhelmshöhe. The journey, including transfers, takes approximately 3h 4m.
Twiste to Frankfurt am Main train services, operated by Deutsche Bahn Regio (DB Regional), depart from Twistetal-Twiste Bahnhof station.
Twiste to Frankfurt am Main train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Frankfurt station.
The distance between Twiste and Frankfurt am Main is 137.1 km. The road distance is 250 km.
You can take a train from Twistetal-Twiste Bahnhof to Frankfurt via Kassel Bahnhof Wilhelmshöhe in around 2h 51m.