The average train between Twyford and Southampton takes 1h 5m and the fastest train takes 1h. There is a train service every few hours from Twyford to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Twyford and Southampton. The earliest departure is at 7:37 AM in the morning, and the last departure from Twyford is at 10:38 PM which arrives into Southampton at 11:45 PM. All services require a transfer, and take on average 1h 5m. The schedules shown below are for the next available departures.

1h 10m • 1 change

1h 5m • 1 change

1h 3m • 1 change

1h 7m • 1 change

1h 10m • 1 change

1h 4m • 1 change

1h 4m • 1 change

1h 4m • 1 change

1h 9m • 1 change

1h 9m • 1 change

1h 10m • 1 change

1h 9m • 1 change

1h 1m • 1 change

1h • 1 change

1h 2m • 1 change

1h 1m • 1 change
Want to know about travelling from Twyford to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Twyford to Southampton. However, there are services departing from Twyford station and arriving at Southampton station via Southampton Central. The journey, including transfers, takes approximately 1h 5m.
Twyford to Southampton train services, operated by Elizabeth Line (TfL), depart from Reading station.
Twyford to Southampton train services, operated by Elizabeth Line (TfL), arrive at Southampton Central station.
Book your Twyford to Southampton train tickets online with Elizabeth Line (TfL), Cross Country and Great Western Railway (GWR).
The distance between Twyford and Southampton is 74.2 km. The road distance is 83 km.
Cross Country operates a train from Reading to Southampton Central hourly. Tickets cost £25–40 and the journey takes 51 min.