The average train between Uxbridge and Holyhead takes 4h 48m and the fastest train takes 4h 36m. The train service runs several times per day from Uxbridge to Holyhead. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Uxbridge and Holyhead. The earliest departure is at 7:01 AM in the morning, and the last departure from Uxbridge is at 7:09 PM which arrives into Holyhead at 11:53 PM. All services require a transfer at King's Cross St. Pancras station and take an average of 4h 48m. The schedules shown below are for the next available departures.

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Want to know about travelling from Uxbridge to Holyhead? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Uxbridge to Holyhead. However, there are services departing from Uxbridge station and arriving at Holyhead station via Holyhead. The journey, including transfers, takes approximately 4h 48m.
Uxbridge to Holyhead train services, operated by London Underground (Tube), depart from London Euston station.
Uxbridge to Holyhead train services, operated by London Underground (Tube), arrive at Holyhead station.
The distance between Uxbridge and Holyhead is 342.8 km. The road distance is 451 km.
Avanti West Coast operates a train from London Euston to Holyhead 5 times a day. Tickets cost £95–160 and the journey takes 3h 52m.