The average train between Uxbridge and Penzance takes 5h 52m and the fastest train takes 5h 20m. The train service runs several times per day from Uxbridge to Penzance. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Uxbridge and Penzance. The earliest departure is at 5:38 AM in the morning, and the last departure from Uxbridge is at 11:08 PM which arrives into Penzance at 7:55 AM. All services require a transfer, and take on average 5h 52m. The schedules shown below are for the next available departures.

6h 1m • 1 change

5h 28m • 1 change

5h 24m • 1 change

5h 44m • 1 change

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6h 3m • 1 change

5h 38m • 1 change

5h 30m • 1 change

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5h 54m • 1 change

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5h 26m • 1 change

6h 1m • 1 change

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5h 24m • 1 change

5h 44m • 1 change
Want to know about travelling from Uxbridge to Penzance? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Uxbridge to Penzance. However, there are services departing from Uxbridge station and arriving at Penzance station via Penzance. The journey, including transfers, takes approximately 5h 52m.
Uxbridge to Penzance train services, operated by Elizabeth Line (TfL), depart from Reading station.
Uxbridge to Penzance train services, operated by Elizabeth Line (TfL), arrive at Penzance station.
Book your Uxbridge to Penzance train tickets online with Elizabeth Line (TfL) and Great Western Railway (GWR).
The distance between Uxbridge and Penzance is 388.9 km. The road distance is 466 km.
Great Western Railway (GWR) operates a train from Reading to Penzance every 2 hours. Tickets cost £120–230 and the journey takes 7h 6m.