The average train between Uxbridge and Plymouth takes 3h 48m and the fastest train takes 3h 25m. There is a train service every few hours from Uxbridge to Plymouth. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Uxbridge and Plymouth. The earliest departure is at 5:38 AM in the morning, and the last departure from Uxbridge is at 11:08 PM which arrives into Plymouth at 5:37 AM. All services require a transfer, and take on average 3h 48m. The schedules shown below are for the next available departures.

4h 3m • 1 change

3h 31m • 1 change

3h 35m • 1 change

3h 25m • 1 change

4h 3m • 1 change

3h 31m • 1 change

3h 35m • 1 change

3h 25m • 1 change

4h 3m • 1 change

3h 31m • 1 change

3h 35m • 1 change

3h 25m • 1 change
Want to know about travelling from Uxbridge to Plymouth? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Uxbridge to Plymouth. However, there are services departing from Uxbridge station and arriving at Plymouth station via Plymouth. The journey, including transfers, takes approximately 3h 48m.
Uxbridge to Plymouth train services, operated by Elizabeth Line (TfL), depart from Reading station.
Uxbridge to Plymouth train services, operated by Elizabeth Line (TfL), arrive at Plymouth station.
Book your Uxbridge to Plymouth train tickets online with Elizabeth Line (TfL) and Great Western Railway (GWR).
The distance between Uxbridge and Plymouth is 287.8 km. The road distance is 339 km.
Great Western Railway (GWR) operates a train from Reading to Plymouth hourly. Tickets cost £80–160 and the journey takes 2h 47m.