The average train between Venice and Mendrisio takes 5h 36m and the fastest train takes 5h 19m. The train service runs several times per day from Venice to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Venice and Mendrisio. The earliest departure is at 11:48 AM in the morning, and the last departure from Venice is at 4:22 PM which arrives into Mendrisio at 9:41 PM. All services require a transfer, and take on average 5h 36m. The schedules shown below are for the next available departures.

5h 53m • 1 change

5h 53m • 1 change

5h 19m • 1 change

5h 19m • 1 change

5h 53m • 1 change

5h 53m • 1 change

5h 19m • 1 change

5h 19m • 1 change

5h 53m • 1 change

5h 53m • 1 change

5h 19m • 1 change

5h 19m • 1 change

5h 53m • 1 change

5h 53m • 1 change

5h 19m • 1 change

5h 19m • 1 change

5h 53m • 1 change

5h 53m • 1 change

5h 19m • 1 change

5h 19m • 1 change
Want to know about travelling from Venice to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Venice to Mendrisio. However, there are services departing from Venice station and arriving at Mendrisio station via Milano Centrale. The journey, including transfers, takes approximately 5h 36m.
Venice to Mendrisio train services, operated by Trenitalia Frecce, depart from Venezia S. Lucia station.
Venice to Mendrisio train services, operated by Trenitalia Frecce, arrive at Mendrisio station.
The distance between Venice and Mendrisio is 264.4 km. The road distance is 324 km.
You can take a train from Venezia S. Lucia to Mendrisio via Milano Centrale in around 4h 1m.