The average train between Wetzlar and Karlsruhe takes 3h 4m and the fastest train takes 2h 47m. The train service runs several times per day from Wetzlar to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Wetzlar and Karlsruhe. The earliest departure is at 6:44 AM in the morning, and the last departure from Wetzlar is at 8:32 PM which arrives into Karlsruhe at 11:23 PM. All services require a transfer at Gießen Bahnhof and take an average of 3h 4m. The schedules shown below are for the next available departures.


3h 15m • 2 changes


2h 47m • 2 changes


3h 27m • 2 changes


2h 47m • 2 changes


3h 15m • 2 changes


2h 47m • 2 changes


3h 27m • 2 changes


2h 47m • 2 changes


3h 15m • 2 changes


2h 47m • 2 changes


3h 27m • 2 changes


2h 47m • 2 changes


3h 15m • 2 changes


2h 47m • 2 changes


3h 27m • 2 changes


2h 47m • 2 changes


2h 47m • 2 changes


2h 47m • 2 changes


2h 47m • 2 changes


3h 27m • 2 changes


2h 47m • 2 changes


2h 47m • 2 changes


2h 47m • 2 changes


3h 27m • 2 changes
Want to know about travelling from Wetzlar to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Wetzlar to Karlsruhe. However, there are services departing from Wetzlar station and arriving at Karlsruhe station via Frankfurt. The journey, including transfers, takes approximately 3h 4m.
Wetzlar to Karlsruhe train services, operated by Deutsche Bahn Regio (DB Regional), depart from Gießen Bahnhof station.
Wetzlar to Karlsruhe train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Karlsruhe Hauptbahnhof station.
Book your Wetzlar to Karlsruhe train tickets online with Deutsche Bahn Regio (DB Regional) and Deutsche Bahn Intercity (DB IC).
The distance between Wetzlar and Karlsruhe is 172.7 km. The road distance is 215 km.
You can take a train from Wetzlar Bahnhof to Karlsruhe Hauptbahnhof via Gießen Bahnhof and Frankfurt in around 3h 23m.