The average train between Wuppertal and Brussels takes 3h 1m and the fastest train takes 2h 31m. The train service runs several times per day from Wuppertal to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Wuppertal and Brussels. The earliest departure is at 5:20 AM in the morning, and the last departure from Wuppertal is at 6:04 PM which arrives into Brussels at 8:35 PM. All services require a transfer, and take on average 3h 1m. The schedules shown below are for the next available departures.

3h 17m • 1 change

3h 17m • 1 change

2h 33m • 1 change

2h 33m • 1 change
Want to know about travelling from Wuppertal to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Wuppertal to Brussels. However, there are services departing from Wuppertal station and arriving at Brussels station via Köln Hbf. The journey, including transfers, takes approximately 3h 1m.
Wuppertal to Brussels train services, operated by National Express, depart from Wuppertal Hbf station.
Wuppertal to Brussels train services, operated by National Express, arrive at Brussel-Zuid / Bruxelles-Midi station.
Book your Wuppertal to Brussels train tickets online with National Express and Eurostar.
The distance between Wuppertal and Brussels is 200.8 km. The road distance is 265 km.
You can take a train from Wuppertal Hbf to Brussel-Zuid / Bruxelles-Midi via Koeln Hbf in around 3h 26m.