The average train between Wuppertal and Enschede takes 3h 17m and the fastest train takes 2h 44m. The train service runs several times per day from Wuppertal to Enschede. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Wuppertal and Enschede. The earliest departure is at 5:56 AM in the morning, and the last departure from Wuppertal is at 10:43 PM which arrives into Enschede at 6:20 AM. All services require a transfer, and take on average 3h 17m. The schedules shown below are for the next available departures.

2h 44m • 1 change
Arrives next day

3h 31m • 1 change
Arrives next day

7h 37m • 1 change

3h 31m • 1 change

3h 31m • 1 change

2h 45m • 1 change

3h 31m • 1 change

3h 31m • 1 change

3h 31m • 1 change

2h 45m • 1 change

3h 31m • 1 change
Want to know about travelling from Wuppertal to Enschede? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Wuppertal to Enschede. However, there are services departing from Wuppertal station and arriving at Enschede station via Münster Hauptbahnhof. The journey, including transfers, takes approximately 3h 17m.
Wuppertal to Enschede train services, operated by Deutsche Bahn Intercity (DB IC), depart from Wuppertal Hbf station.
Wuppertal to Enschede train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Enschede station.
Book your Wuppertal to Enschede train tickets online with Deutsche Bahn Intercity (DB IC), Deutsche Bahn Regio (DB Regional) and National Express.
The distance between Wuppertal and Enschede is 108.4 km. The road distance is 170 km.
You can take a train from Wuppertal Hbf to Enschede via Münster Hauptbahnhof in around 3h 9m.