The average train between Zurich and Isernia takes 13h 59m and the fastest train takes 10h 7m. The train service runs several times per day from Zurich to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Zurich and Isernia. The earliest departure is at 6:33 AM in the morning, and the last departure from Zurich is at 7:33 PM which arrives into Isernia at 3:23 PM. All services require a transfer at Como S. Giovanni and take an average of 13h 59m. The schedules shown below are for the next available departures.



10h 7m • 3 changes


10h 22m • 3 changes


10h 50m • 3 changesArrives next day



16h 54m • 3 changesWant to know about travelling from Zurich to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Zurich to Isernia. However, there are services departing from Zürich HB station and arriving at Isernia station via Como S. Giovanni station, Milano Centrale station and Roma Termini station. The journey, including transfers, takes approximately 13h 59m.
Zurich to Isernia train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Zürich HB station.
Zurich to Isernia train services, operated by Trenitalia, arrive at Isernia station.
Book your Zurich to Isernia train tickets online with Omio.
The distance between Zurich and Isernia is 783.8 km. The road distance is 1004 km.
You can take a train from Zürich HB to Isernia via Como S. Giovanni, Milano Centrale, and Roma Termini in around 10h 23m.