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How to get fromAlachua to Florenceby car, train, bus (Flixbus), plane, or bus

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There are 6 ways to get from Alachua to Florence by car, train, bus (Flixbus), plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, train (Amtrak)

    best
    1. Drive from Alachua to Jacksonvillecar car
    2. Take the train from Jacksonville to Florence Stationtrain train Silver Meteor
    7h 44m
    $123–249

  2. Drive 372.3 mi

    cheapest
    1. Drive from Alachua to Florencecar car 372.3 mi
    6h 32m
    $68–99

  3. Bus

    1. Take the bus from Gainesville to Jacksonvillebus bus FlixBus 2431
    2. Take the bus from Jacksonville to Florence Bus Stationbus bus FlixBus 2433
    9h 25m

  4. Fly to Florence Regional Airport

    1. Fly from Gainesville Regional Airport (GNV) to Florence Regional Airport (FLO)plane plane GNV - FLO
    4h 49m
    $143–439

  5. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus FlixBus 2431
    2. Take the train from Jacksonville to Florence Stationtrain train Silver Meteor
    9h 55m
    $176–316

  6. Fly to Myrtle Beach, bus

    1. Fly from Gainesville Regional Airport (GNV) to Myrtle Beach (MYR)plane plane GNV - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    6h 35m

Gainesville Regional Airport (GNV) to Florence Regional Airport (FLO) flights

Calendar35Weekly Planes
Duration6h 51mAverage Duration
Ticket$61Cheapest Price
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Questions & Answers

Map of how to get from Alachua to Florence.ExpandLaunch map view
  • Distance: 415 mi
  • Duration: 7h 44m

What companies run services between Alachua, FL, USA and Florence, SC, USA?

You can take a vehicle from Alachua to Florence Bus Station via Santa Fe, Rosa Parks RTS Downtown Station, Gainesville, and Jacksonville in around 9h 25m. Alternatively, American Airlines flies from Gainesville Regional Airport (GNV) to Florence Regional Airport (FLO) 5 times a day.

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