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How to get fromAlton to Knoxvilleby plane, train, bus, bus (Greyhound), or car

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There are 6 ways to get from Alton to Knoxville by plane, train, bus, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    4h 45m
    $225–879

  2. Drive 498.2 mi

    cheapest
    1. Drive from Alton to Knoxvillecar car 498.2 mi
    8h 21m
    $91–132

  3. Train, bus

    1. Take the train from Alton Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 2m
    $573–1,085

  4. Bus

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York to Knoxvillebus bus Nyc
    40h 39m
    $366–591

  5. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Chattanooga Metropolitan Airport (CHA)plane plane STL - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 54m
    $228–987

  6. Train, bus via Ossining

    1. Take the train from Alton Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    39h 32m
    $528–1,012

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar113Weekly Planes
Duration5h 2mAverage Duration
Ticket$128Cheapest Price
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Questions & Answers

Map of how to get from Alton to Knoxville.ExpandLaunch map view
  • Distance: 437.5 mi
  • Duration: 4h 45m

What companies run services between Alton, IL, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a vehicle from Alton to Knoxville via North County Transit Center, Civic Center Transit Center, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 40h 39m.

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