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How to get fromAltoona to Knoxvilleby train, plane, bus, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Altoona to Knoxville by train, plane, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Johnstown-Cambria County Airport, fly

    best
    1. Take the train from Altoona Amtrak Station to Johnstown Amtrak Stationtrain train
    2. Fly from Johnstown-Cambria County Airport (JST) to Mcghee Tyson Airport (TYS)plane plane JST - TYS
    6h 25m
    $191–763

  2. Drive 537.6 mi

    cheapest
    1. Drive from Altoona to Knoxvillecar car 537.6 mi
    9h 22m
    $99–142

  3. Train, bus via Philadelphia

    1. Take the train from Altoona Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    20h 11m
    $234–916

  4. Bus to Penn State University Park Airport, fly

    1. Take the bus from Altoona Bus Station to State College Bus Stationbus bus
    2. Fly from Penn State University Park Airport (SCE) to Mcghee Tyson Airport (TYS)plane plane SCE - TYS
    7h 16m
    $173–736

  5. Fly from Altoona–Blair County Airport

    1. Fly from Altoona–Blair County Airport (AOO) to Mcghee Tyson Airport (TYS)plane plane AOO - TYS
    4h 52m
    $386–1,230

  6. Train, bus

    1. Take the train from Altoona Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Pennsylvanian
    2. Take the bus from New York to Knoxvillebus bus Nyc
    20h 20m
    $289–466

  7. Bus

    1. Take the bus from Altoona Bus Station to Harrisburg Bus Stationbus bus
    2. Take the bus from Harrisburg Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    25h 27m
    $154–218

Johnstown-Cambria County Airport (JST) to Mcghee Tyson Airport (TYS) flights

Calendar16Weekly Planes
Duration6h 13mAverage Duration
Ticket$114Cheapest Price
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Questions & Answers

Map of how to get from Altoona to Knoxville.ExpandLaunch map view
  • Distance: 474.9 mi
  • Duration: 6h 25m

What companies run services between Altoona, PA, USA and Knoxville, TN, USA?

Corporate Flight Management Inc, American Airlines, and Delta fly from Altoona–Blair County Airport (AOO) to Mcghee Tyson Airport (TYS) twice daily. Alternatively, you can take a bus from Altoona Bus Station to Knoxville Station Hall of Fame via Harrisburg Bus Station, New York, NY, Knoxville, TN, Walmart, and Fountain City Superstop in around 25h 27m.

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