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How to get fromAltoona to Mayo Clinicby bus, plane, train, bus (Greyhound, Flixbus), or car

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There are 9 ways to get from Altoona to Mayo Clinic by bus, plane, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Penn State University Park Airport, fly to Rochester

    best
    1. Take the bus from Altoona Bus Station to State College Bus Stationbus bus
    2. Fly from Penn State University Park Airport (SCE) to Rochester (RST)plane plane SCE - RST
    8h 43m
    $89–466

  2. Train, bus via Madison

    1. Take the train from Altoona Amtrak Station to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    23h 41m
    $262–525

  3. Bus

    1. Take the bus from Altoona Bus Station to Pittsburgh Intermodal Stationbus bus
    2. Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    24h 13m
    $170–298

  4. Drive 890.2 mi

    1. Drive from Altoona to Mayo Cliniccar car 890.2 mi
    15h 23m
    $163–235

  5. Train to Pittsburgh International Airport, fly to Rochester

    1. Take the train from Altoona Amtrak Station to Pittsburgh Amtrak Stationtrain train
    2. Fly from Pittsburgh International Airport (PIT) to Rochester (RST)plane plane PIT - RST
    10h 53m
    $123–555

  6. Train to Pittsburgh International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Altoona Amtrak Station to Pittsburgh Amtrak Stationtrain train
    2. Fly from Pittsburgh International Airport (PIT) to Minneapolis–Saint Paul International Airport (MSP)plane plane PIT - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 28m
    $589–1,127

  7. Train to Johnstown-Cambria County Airport, fly to Rochester

    1. Take the train from Altoona Amtrak Station to Johnstown Amtrak Stationtrain train
    2. Fly from Johnstown-Cambria County Airport (JST) to Rochester (RST)plane plane JST - RST
    9h 2m
    $102–483

  8. Train, bus

    1. Take the train from Altoona Amtrak Station to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    24h 44m
    $345–705

  9. Train, bus via Auburn Gresham

    1. Take the train from Altoona Amtrak Station to Pittsburgh Amtrak Stationtrain train
    2. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    26h 14m
    $203–361

Altoona to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration24h 44mAverage Duration
Ticket$345Cheapest Price
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Questions & Answers

Map of how to get from Altoona to Mayo Clinic.ExpandLaunch map view
  • Distance: 832.7 mi
  • Duration: 8h 43m

What companies run services between Altoona, PA, USA and Mayo Clinic, MN, USA?

You can take a bus from Altoona Bus Station to Mayo Clinic via Pittsburgh Intermodal Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 24h 13m.

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Train operators
Bus operators

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