Rome2Rio

How to get fromAmes to Great Smoky Mountainsby shuttle, plane, car, bus, or train

Find Transport to Great Smoky Mountains

See all options

There are 10 ways to get from Ames to Great Smoky Mountains by shuttle, plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Des Moines, fly to Mcghee Tyson Airport, drive

    best
    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 53m
    $302–1,306

  2. Drive 878.8 mi

    cheapest
    1. Drive from Ames to Great Smoky Mountainscar car 878.8 mi
    16h 14m
    $161–232

  3. Shuttle, bus, train, drive

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    3. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    4. Take the bus from Ashland Bus Station to Winston Salem(Trans Center)bus bus
    5. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    6. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    34h 9m
    $341–693

  4. Bus, train, drive

    1. Take the bus from Ames to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Carytrain train
    4. Take the train from Cary to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    6. Drive from Asheville, NC to Great Smoky Mountainscar car
    46h 32m
    $590–1,220

  5. Shuttle to Des Moines, fly to Asheville Regional Airport, drive

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    7h 47m
    $216–862

  6. Shuttle to Des Moines, fly to Greenville–Spartanburg International Airport, drive

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP)plane plane DSM - GSP
    3. Drive from Greenville–Spartanburg International Airport (GSP) to Great Smoky Mountainscar car
    8h 54m
    $296–1,175

  7. Shuttle to Des Moines, fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane DSM - ATL
    3. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    8h 1m
    $267–1,045

  8. Shuttle to Des Moines, fly to Nashville, drive

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    3. Drive from Nashville-Airport-BNA to Great Smoky Mountainscar car
    7h 57m
    $222–855

  9. Bus to Minneapolis–Saint Paul International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Ames to St. Paulbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS)plane plane MSP - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    9h 43m
    $240–949

  10. Bus, drive

    1. Take the bus from Ames to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    5. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    6. Drive from Asheville, NC to Great Smoky Mountainscar car
    35h 13m
    $259–486

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar83Weekly Planes
Duration5h 15mAverage Duration
Ticket$216Cheapest Price
See schedules

Questions & Answers

Map of how to get from Ames to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 754.1 mi
  • Duration: 7h 53m

What companies run services between Ames, IA, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Ames to Great Smoky Mountains. However, you can take the shuttle to Des Moines International Airport, IA, walk to Des Moines (DSM) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a shuttle from Ames, IA - Iowa State University to Great Smoky Mountains via Des Moines International Airport, IA, Des Moines, Indianapolis Union Station, Indianapolis, Ashland Amtrak Station, Ashland Bus Station, Winston Salem(Trans Center), Asheville, NC, ART Station, and New Leicester Hwy at Walgreens in around 34h 9m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound