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How to get fromAmes to Knoxvilleby shuttle, plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Ames to Knoxville by shuttle, plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle, fly to Mcghee Tyson Airport

    best
    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    6h 7m
    $337–1,360

  2. Drive  822.4 mi

    cheapest
    1. Drive from Ames to Knoxvillecar car 822.4 mi
    14h 25m
    $151–217

  3. Bus, train

    1. Take the bus from Ames to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    47h 12m
    $591–1,183

  4. Shuttle, bus

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Take the bus from Des Moines to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    47h 52m
    $394–683

  5. Shuttle, fly to Nashville, drive

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 10m
    $197–740

  6. Shuttle, fly to Asheville Regional Airport, drive

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 58m
    $204–775

  7. Bus, train via Ossining

    1. Take the bus from Ames to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    47h 48m
    $546–1,060

  8. Bus

    1. Take the bus from Ames to St. Paulbus bus
    2. Take the bus from Saint Paul Union Depot to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 3h
    $357–565

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar81Weekly Planes
Duration5h 10mAverage Duration
Ticket$203Cheapest Price
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Questions & Answers

Map of how to get from Ames to Knoxville.ExpandLaunch map view
  • Distance: 707.7 mi
  • Duration: 6h 7m

What companies run services between Ames, IA, USA and Knoxville, TN, USA?

You can take a bus from Ames to Knoxville Station Hall of Fame via Saint Paul Union Depot, Chicago Bus Station, New York, NY, Knoxville, TN, Walmart, and Fountain City Superstop in around 2d 3h.

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