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How to get fromAmes to Knoxvilleby shuttle, plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 9 ways to get from Ames to Knoxville by shuttle, plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Des Moines, fly to Mcghee Tyson Airport

    best
    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    6h 19m
    $367–1,460

  2. Drive 822.4 mi

    cheapest
    1. Drive from Ames to Knoxvillecar car 822.4 mi
    14h 25m
    $151–217

  3. Bus, train

    1. Take the bus from Ames to Des Moinesbus bus
    2. Take the bus from Des Moines to Chicago Bus Stationbus bus
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    43h 44m
    $568–1,040

  4. Bus

    1. Take the bus from Ames to Des Moinesbus bus
    2. Take the bus from Des Moines to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    47h 35m
    $334–512

  5. Shuttle to Des Moines, fly to Nashville, drive

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 12m
    $222–840

  6. Shuttle to Des Moines, fly to Asheville Regional Airport, drive

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 55m
    $234–875

  7. Bus to Minneapolis–Saint Paul International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Ames to MSP Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS)plane plane MSP - TYS
    7h 23m
    $282–1,049

  8. Bus, train via Galesburg

    1. Take the bus from Ames to Des Moinesbus bus
    2. Take the bus from Des Moines to Galesburgbus bus
    3. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    44h 59m
    $548–1,015

  9. Bus, train via Saint Paul

    1. Take the bus from Ames to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    47h 59m
    $637–1,182

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar83Weekly Planes
Duration5h 15mAverage Duration
Ticket$230Cheapest Price
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Questions & Answers

Map of how to get from Ames to Knoxville.ExpandLaunch map view
  • Distance: 707.7 mi
  • Duration: 6h 19m

What companies run services between Ames, IA, USA and Knoxville, TN, USA?

You can take a bus from Ames to Knoxville Station Hall of Fame via Des Moines, Chicago Bus Station, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 47h 35m.

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