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How to get fromAmes to Mayo Clinicby bus, car, shuttle, or plane

Find Transport to Mayo Clinic

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There are 3 ways to get from Ames to Mayo Clinic by bus, car, shuttle, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Ames to Owatonnabus bus Jefferson Lines 802 / ...
    2. Take the bus from Owatonna to Rochesterbus bus Lta 239 / ...
    4h 38m
    $50–101
  2. Drive  178.6 mi

    cheapest
    1. Drive from Ames to Mayo Cliniccar car 178.6 mi
    2h 59m
    $33–48
  3. Shuttle, fly

    1. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    2. Fly from Des Moines (DSM) to Rochester (RST)plane plane DSM - RST
    7h 4m
    $143–640

Ames to Mayo Clinic by bus and foot

Calendar14Weekly Services
Duration4h 38mAverage Duration
Ticket$50Cheapest Price
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Comparing Your Travel Options

What companies run services between Ames, IA, USA and Mayo Clinic, MN, USA?

You can take a bus from Ames to Mayo Clinic via Owatonna and Rochester in around 4h 38m.

Airlines
Bus operators

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