There are 4 ways to get from Ames to Mayo Clinic by bus, car, shuttle, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Ames to St. Paulbus Jefferson Lines 802 / ...
- Take the bus from St. Paul to Rochesterbus Jefferson Lines 965
6h 28m$86–120Drive 178.6 mi
cheapest- Drive from Ames to Mayo Cliniccar 178.6 mi
2h 59m$33–48Shuttle, fly
- Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IA
- Fly from Des Moines (DSM) to Rochester (RST)plane DSM - RST
6h 56m$153–710Bus via Minneapolis Airport (MSP)
- Take the bus from Ames to St. Paulbus Jefferson Lines 802 / ...
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus Groome Transportation
7h 50m$110–133
Ames to Mayo Clinic by bus and foot
Comparing Your Travel Options
The cheapest way to get from Ames to Mayo Clinic is to drive which costs $30 - $50 and takes 2h 59m.
The fastest way to get from Ames to Mayo Clinic is to drive which takes 2h 59m and costs $30 - $50.
No, there is no direct bus from Ames to Mayo Clinic. However, there are services departing from Ames and arriving at Rochester via St. Paul. The journey, including transfers, takes approximately 6h 28m.
The distance between Ames and Mayo Clinic is 300 miles. The road distance is 179.6 miles.
The best way to get from Ames to Mayo Clinic without a car is to bus which takes 6h 28m and costs $85 - $120.
It takes approximately 6h 28m to get from Ames to Mayo Clinic, including transfers.
Ames to Mayo Clinic bus services, operated by Jefferson Lines, depart from Ames station.
Ames to Mayo Clinic bus services, operated by Jefferson Lines, arrive at St. Paul station.
Yes, the driving distance between Ames to Mayo Clinic is 180 miles. It takes approximately 2h 59m to drive from Ames to Mayo Clinic.
There are 77+ hotels available in Mayo Clinic.
What companies run services between Ames, IA, USA and Mayo Clinic, MN, USA?
You can take a bus from Ames to Mayo Clinic via St. Paul and Rochester in around 6h 28m.
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Ames to St. Paul
- Ave. Duration
- 3h 55m
- Frequency
- Twice daily
- Estimated price
- $55–80
- Book at
- Jefferson Lines
- Adult
- $55–80
Bus from St. Paul to Rochester
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- $28–40
- Book at
- Jefferson Lines
- Adult
- $28–40
Bus from Ames to St. Paul
- Ave. Duration
- 3h 55m
- Frequency
- Twice daily
- Estimated price
- $55–80
- Book at
- Jefferson Lines
- Adult
- $55–80
- Phone
- +1 320.253.2226
- Website
- Executive Express
Shuttle from Ames, IA - Iowa State University to Des Moines International Airport, IA
- Ave. Duration
- 45 min
- Frequency
- On demand
- Estimated price
- $80–190
- Website
- Executive Express
- Schedules at
- Executive Express Coverage Areas for Minnesota and Iowa
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
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