There are 3 ways to get from Ames to Mayo Clinic by bus, car, shuttle, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Ames to Owatonnabus Jefferson Lines 802 / ...
- Take the bus from Owatonna to Rochesterbus Lta 239 / ...
4h 38m$50–101Drive 178.6 mi
cheapest- Drive from Ames to Mayo Cliniccar 178.6 mi
2h 59m$33–48Shuttle, fly
- Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IA
- Fly from Des Moines (DSM) to Rochester (RST)plane DSM - RST
7h 4m$143–640
Ames to Mayo Clinic by bus and foot
Comparing Your Travel Options
The cheapest way to get from Ames to Mayo Clinic is to drive which costs $30 - $50 and takes 2h 59m.
The fastest way to get from Ames to Mayo Clinic is to drive which takes 2h 59m and costs $30 - $50.
No, there is no direct bus from Ames to Mayo Clinic. However, there are services departing from Ames and arriving at Rochester via Owatonna. The journey, including transfers, takes approximately 4h 38m.
The distance between Ames and Mayo Clinic is 198 miles. The road distance is 179.6 miles.
The best way to get from Ames to Mayo Clinic without a car is to bus which takes 4h 38m and costs $45 - $110.
It takes approximately 4h 38m to get from Ames to Mayo Clinic, including transfers.
Ames to Mayo Clinic bus services, operated by Jefferson Lines, depart from Ames station.
Ames to Mayo Clinic bus services, operated by Jefferson Lines, arrive at Owatonna station.
Yes, the driving distance between Ames to Mayo Clinic is 180 miles. It takes approximately 2h 59m to drive from Ames to Mayo Clinic.
There are 80+ hotels available in Mayo Clinic.
What companies run services between Ames, IA, USA and Mayo Clinic, MN, USA?
You can take a bus from Ames to Mayo Clinic via Owatonna and Rochester in around 4h 38m.
- Website
- delta.com
Flights from Des Moines to Rochester via Minneapolis
- Ave. Duration
- 4h 24m
- When
- Every day
- Estimated price
- $60–410
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Ames to Owatonna
- Ave. Duration
- 2h 45m
- Frequency
- 3 times a day
- Estimated price
- $40–65
- Book at
- Jefferson Lines
- Adult
- $40–65
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide



