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How to get fromAmherst to Knoxvilleby plane, train, bus, car, bus (Greyhound), or bus (Flixbus)

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There are 7 ways to get from Amherst to Knoxville by plane, train, bus, car, bus (Greyhound), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    4h 17m
    $253–1,053

  2. Drive 690.5 mi

    cheapest
    1. Drive from Amherst to Knoxvillecar car 690.5 mi
    11h 36m
    $126–182

  3. Train, bus

    1. Take the train from Buffalo to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    22h 33m
    $277–487

  4. Fly to Nashville, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Nashville (BNA)plane plane BUF - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 55m
    $153–633

  5. Bus

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus Greyhound US0205 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    23h 43m
    $240–505

  6. Bus via Wilkeson Way & LaRivere Drive

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus N2686 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    24h 9m
    $255–375

  7. Train, bus via Farragut

    1. Take the train from Buffalo to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    26h 45m
    $299–549

Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) flights

Calendar90Weekly Planes
Duration4h 50mAverage Duration
Ticket$178Cheapest Price
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Questions & Answers

Map of how to get from Amherst to Knoxville.ExpandLaunch map view
  • Distance: 587.2 mi
  • Duration: 4h 17m

What companies run services between Amherst, NY, USA and Knoxville, TN, USA?

Delta, United Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Main Street & University Station to Knoxville via South Division Street & Ellicott Loop, Buffalo, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 23h 43m.

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