There are 4 ways to get from Anaheim to Otay Mesa by bus (Greyhound, Flixbus), train, tram, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Anaheim Regional Transportation Intermodal Center to San Ysidro Bus Terminalbus Greyhound US0901 / ...
3h 31m$22–39Drive 111.2 mi
cheapest- Drive from Anaheim to Otay Mesacar 111.2 mi
2h$19–28Train, tram
- Take the train from Fullerton Amtrak Station to San Diego Old Town Transportation Centertrain Pacific Surfliner
- Take the tram from Old Town Station to Iris Avenue Stationtram Blue
3h 43m$58–101Bus, line 929 bus
- Take the bus from Anaheim to San Diegobus Los Angeles
- Take the bus from 12th & Imperial Transit Center to Iris Avenue Transit Centerbus 929 / ...
4h$22–37
Anaheim to Otay Mesa by bus
Comparing Your Travel Options
The cheapest way to get from Anaheim to Otay Mesa is to drive which costs $19 - $28 and takes 2h.
The fastest way to get from Anaheim to Otay Mesa is to drive which takes 2h and costs $19 - $28.
No, there is no direct bus from Anaheim to Otay Mesa. However, there are services departing from Anaheim Regional Transportation Intermodal Center and arriving at Otay Mesa Rd & Cactus Rd via San Ysidro Transit Center and Iris Avenue Transit Center. The journey, including transfers, takes approximately 3h 31m.
No, there is no direct train from Anaheim station to Otay Mesa station. However, there are services departing from Fullerton Amtrak Station and arriving at Iris Avenue Station via Old Town Station. The journey, including transfers, takes approximately 3h 43m.
The distance between Anaheim and Otay Mesa is 118 miles. The road distance is 111.9 miles.
The best way to get from Anaheim to Otay Mesa without a car is to bus which takes 3h 31m and costs $21 - $40.
It takes approximately 3h 31m to get from Anaheim to Otay Mesa, including transfers.
Anaheim to Otay Mesa bus services, operated by Greyhound USA, depart from Anaheim Regional Transportation Intermodal Center station.
Anaheim to Otay Mesa train services, operated by Amtrak, depart from Fullerton Amtrak Station.
Anaheim to Otay Mesa bus services, operated by Greyhound USA, arrive at San Ysidro Bus Terminal station.
What companies run services between Anaheim, CA, USA and Otay Mesa, CA, USA?
Greyhound USA operates a bus from Anaheim Regional Transportation Intermodal Center to San Ysidro Bus Terminal 3 times a day. Tickets cost $19–30 and the journey takes 2h 30m. Flixbus USA also services this route twice daily.
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Fullerton Amtrak Station to San Diego Old Town Transportation Center
- Ave. Duration
- 2h 11m
- Frequency
- Hourly
- Estimated price
- $50–85
- Website
- Amtrak
- Phone
- +1 619-557-4555
- Website
- MTS
Tram from Old Town Station to Iris Avenue Station
- Ave. Duration
- 50 min
- Frequency
- Every 20 minutes
- Estimated price
- $2–12
- Website
- MTS
- Schedules at
- MTS Schedules
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Anaheim Regional Transportation Intermodal Center to San Ysidro Bus Terminal
- Ave. Duration
- 2h 30m
- Frequency
- 3 times a day
- Estimated price
- $19–30
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Anaheim Regional Transportation Intermodal Center to San Ysidro Bus Terminal
- Ave. Duration
- 2h 5m
- Frequency
- Twice daily
- Estimated price
- $17–26
- Schedules at
- Flixbus USA
- Phone
- +1-800-231-2222
- [email protected]
- Website
- Greyhound Mexico
Bus from Anaheim to San Diego
- Ave. Duration
- 2h 10m
- Frequency
- Twice daily
- Estimated price
- $17–27
- Schedules at
- Greyhound Mexico
- Phone
- +1 619-557-4555
- Website
- MTS
Bus from 12th & Imperial Transit Center to Iris Avenue Transit Center
- Ave. Duration
- 1h 11m
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- MTS
- Schedules at
- MTS Schedules
- One Way - Adult/Youth
- $2–5
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
Booking & Getting There
Anaheim to Otay Mesa train services, operated by Amtrak, arrive at San Diego Old Town Transportation Center station.
Yes, the driving distance between Anaheim to Otay Mesa is 112 miles. It takes approximately 2h to drive from Anaheim to Otay Mesa.
There are 538+ hotels available in Otay Mesa.























