There are 4 ways to get from Anaheim to Otay Mesa by bus (Greyhound, Flixbus), train, tram, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Anaheim Regional Transportation Intermodal Center to San Ysidro Bus Terminalbus Greyhound US0831
3h 32m$22–43Drive 111.2 mi
cheapest- Drive from Anaheim to Otay Mesacar 111.2 mi
2h$21–30Train, tram
- Take the train from Fullerton Amtrak Station to San Diego Old Town Transportation Centertrain Pacific Surfliner
- Take the tram from Old Town Station to Iris Avenue Stationtram Blue
3h 34m$36–82Bus, line 929 bus
- Take the bus from Anaheim to San Diegobus Los Angeles
- Take the bus from 12th & Imperial Transit Center to Iris Avenue Transit Centerbus 929 / ...
3h 51m$24–40
Anaheim to Otay Mesa by bus
Questions & Answers
The cheapest way to get from Anaheim to Otay Mesa is to drive which costs $20 - $30 and takes 2h.
The fastest way to get from Anaheim to Otay Mesa is to drive which takes 2h and costs $20 - $30.
No, there is no direct bus from Anaheim to Otay Mesa. However, there are services departing from Anaheim Regional Transportation Intermodal Center and arriving at Otay Mesa Rd & Cactus Rd via San Ysidro Transit Center and Iris Avenue Transit Center. The journey, including transfers, takes approximately 3h 32m.
No, there is no direct train from Anaheim station to Otay Mesa station. However, there are services departing from Fullerton Amtrak Station and arriving at Iris Avenue Station via Old Town Station. The journey, including transfers, takes approximately 3h 34m.
The distance between Anaheim and Otay Mesa is 120 miles. The road distance is 111.9 miles.
The best way to get from Anaheim to Otay Mesa without a car is to bus which takes 3h 32m and costs $21 - $45.
It takes approximately 3h 32m to get from Anaheim to Otay Mesa, including transfers.
Anaheim to Otay Mesa bus services, operated by Greyhound-us, depart from Anaheim Regional Transportation Intermodal Center station.
Anaheim to Otay Mesa train services, operated by Amtrak, depart from Fullerton Amtrak Station.
Anaheim to Otay Mesa bus services, operated by Greyhound-us, arrive at San Ysidro Bus Terminal station.
What companies run services between Anaheim, CA, USA and Otay Mesa, CA, USA?
Greyhound-us operates a bus from Anaheim Regional Transportation Intermodal Center to San Ysidro Bus Terminal twice daily, and the journey takes 2h 40m. Two other operators also service this route.
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Fullerton Amtrak Station to San Diego Old Town Transportation Center
- Ave. Duration
- 2h 11m
- Frequency
- Hourly
- Estimated price
- $30–65
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 619-557-4555
- Website
- sdmts.com
Tram from Old Town Station to Iris Avenue Station
- Ave. Duration
- 50 min
- Frequency
- Every 20 minutes
- Estimated price
- $2–12
- Website
- https://www.sdmts.com
- Schedules at
- https://www.sdmts.com/getting-around/departures-and-schedules
- Website
- greyhound.com
Bus from Anaheim Regional Transportation Intermodal Center to San Ysidro Bus Terminal
- Ave. Duration
- 2h 40m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Anaheim Regional Transportation Intermodal Center to San Ysidro Bus Terminal
- Ave. Duration
- 2h 40m
- Frequency
- Twice daily
- Estimated price
- $17–35
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Anaheim Regional Transportation Intermodal Center to San Ysidro Bus Terminal
- Ave. Duration
- 2h 20m
- Frequency
- 6 times a week
- Estimated price
- $18–30
- Schedules at
- flixbus.com
- Phone
- +1-800-231-2222
- [email protected]
- Website
- greyhound.com.mx
Bus from Anaheim to San Diego
- Ave. Duration
- 2h 10m
- Frequency
- Twice daily
- Estimated price
- $19–30
- Schedules at
- greyhound.com.mx
- Phone
- +1 619-557-4555
- Website
- sdmts.com
Bus from 12th & Imperial Transit Center to Iris Avenue Transit Center
- Ave. Duration
- 1h 11m
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- https://www.sdmts.com
- Schedules at
- https://www.sdmts.com/getting-around/departures-and-schedules
- One Way - Adult/Youth
- $2–5
Want to know more about travelling around United States
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More Questions & Answers
Anaheim to Otay Mesa train services, operated by Amtrak, arrive at San Diego Old Town Transportation Center station.
Yes, the driving distance between Anaheim to Otay Mesa is 112 miles. It takes approximately 2h to drive from Anaheim to Otay Mesa.
There are 561+ hotels available in Otay Mesa.

















