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How to get fromAnkeny to St. Louisby bus (Greyhound), bus, train, car, plane, or bus (Greyhound, Amtrak, Flixbus)

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There are 6 ways to get from Ankeny to St. Louis by bus (Greyhound), bus, train, car, plane, or bus (Greyhound, Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Kansas City (Greyhound)

    best
    1. Take the bus from Des Moines to Kansas City Bus Stationbus bus Greyhound US0156
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0180s / ...
    8h 27m
    $84–163

  2. Drive  337.6 mi

    cheapest
    1. Drive from Ankeny to St. Louiscar car 337.6 mi
    6h 49m
    $62–89

  3. Bus, train via Kansas City

    1. Take the bus from Des Moines to Kansas City Bus Stationbus bus Greyhound US0156
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    10h 48m
    $124–253

  4. Fly

    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    6h 17m
    $145–842

  5. Bus, train

    1. Take the bus from Des Moines to Bloomington-Normalbus bus Greyhound US0157S
    2. Take the train from Bloomington-Normal to St. Louistrain train Lincoln Service / ...
    10h 17m
    $104–208

  6. Bus

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus
    10h 58m
    $100–168

Des Moines (DSM) to Lambert–St. Louis International Airport (STL) flights

Calendar133Weekly Planes
Duration5h 6mAverage Duration
Ticket$107Cheapest Price
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Questions & Answers

Map of how to get from Ankeny to St. Louis.ExpandLaunch map view
  • Distance: 449.5 mi
  • Duration: 8h 27m

What companies run services between Ankeny, IA, USA and St. Louis, MO, USA?

You can take a vehicle from Ankeny to St Louis Bus Station via Des Moines and Kansas City Bus Station in around 8h 27m. Alternatively, United Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL) hourly.

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Need to know: Greyhound

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