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How to get fromAnn Arbor to Cape Girardeauby train, taxi, bus (Amtrak, Flixbus, Greyhound), car, bus, plane, or bus (Amtrak, Greyhound)

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There are 9 ways to get from Ann Arbor to Cape Girardeau by train, taxi, bus (Amtrak, Flixbus, Greyhound), car, bus, plane, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, taxi

    best
    1. Take the train from Ann Arbor Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Carbondaletrain train
    3. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    11h 48m
    $278–500

  2. Drive 566 mi

    cheapest
    1. Drive from Ann Arbor to Cape Girardeaucar car 566 mi
    9h 39m
    $104–150

  3. Bus via Chicago

    1. Take the bus from Ann Arbor Amtrak Station to Chicago Union Stationbus bus
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    14h 52m
    $157–246

  4. Bus, fly to Williamson County Regional Airport, taxi

    1. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    2. Fly from Detroit (DTW) to Williamson County Regional Airport (MWA)plane plane DTW - MWA
    3. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    7h 20m
    $212–597

  5. Train, bus

    1. Take the train from Ann Arbor Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    13h 13m
    $192–394

  6. Bus

    1. Take the bus from Ann Arbor Amtrak Station to Toledobus bus
    2. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    15h 34m
    $122–225

  7. Bus, fly to Barkley Regional Airport, taxi

    1. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    2. Fly from Detroit (DTW) to Barkley Regional Airport (PAH)plane plane DTW - PAH
    3. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    7h 12m
    $227–637

  8. Bus, fly to Lambert–St. Louis International Airport

    1. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    2. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    7h 10m
    $484–1,014

  9. Bus, fly to Cape Girardeau Municipal Airport

    1. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    2. Fly from Detroit (DTW) to Cape Girardeau Municipal Airport (CGI)plane plane DTW - CGI
    6h 40m
    $190–745

Detroit (DTW) to Williamson County Regional Airport (MWA) flights

Calendar26Weekly Planes
Duration4h 48mAverage Duration
Ticket$76Cheapest Price
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Questions & Answers

Map of how to get from Ann Arbor to Cape Girardeau.ExpandLaunch map view
  • Distance: 597.3 mi
  • Duration: 11h 48m

What companies run services between Ann Arbor, MI, USA and Cape Girardeau, MO, USA?

You can take a bus from Ann Arbor Amtrak Station to Cape Girardeau via Chicago Union Station, Chicago Bus Station, St Louis Bus Station, and Cape Girardeau in around 14h 52m.

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