Rome2Rio

How to get fromAnn Arbor to Knoxvilleby bus, plane, bus (Amtrak, Flixbus), train, car, or bus (Greyhound)

Find Transport to Knoxville

See all options

There are 8 ways to get from Ann Arbor to Knoxville by bus, plane, bus (Amtrak, Flixbus), train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Detroit, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    2. Fly from Detroit (DTW) to Mcghee Tyson Airport (TYS)plane plane DTW - TYS
    3h 40m
    $182–837

  2. Drive 498 mi

    cheapest
    1. Drive from Ann Arbor to Knoxvillecar car 498 mi
    8h 22m
    $91–132

  3. Bus via Toledo

    1. Take the bus from Ann Arbor Amtrak Station to Toledobus bus
    2. Take the bus from Toledo Bus Stop to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    28h 51m
    $316–480

  4. Bus, train via Farragut

    1. Take the bus from Ann Arbor Amtrak Station to Toledobus bus
    2. Take the train from Toledo to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    31h 54m
    $446–780

  5. Drive to Capital Region International Airport, fly to Mcghee Tyson Airport

    1. Drive from Ann Arbor to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Mcghee Tyson Airport (TYS)plane plane LAN - TYS
    6h 3m
    $208–888

  6. Bus to Detroit, fly to Chattanooga Metropolitan Airport, drive

    1. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    2. Fly from Detroit (DTW) to Chattanooga Metropolitan Airport (CHA)plane plane DTW - CHA
    3. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 20m
    $165–895

  7. Bus, train

    1. Take the bus from Ann Arbor Amtrak Station to Toledobus bus
    2. Take the train from Toledo to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    31h 58m
    $401–690

  8. Bus

    1. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit - Grand Circus Parkbus bus
    2. Take the bus from Detroit Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    33h 8m
    $303–473

Detroit (DTW) to Mcghee Tyson Airport (TYS) flights

Calendar61Weekly Planes
Duration3h 28mAverage Duration
Ticket$126Cheapest Price
See schedules

Questions & Answers

Map of how to get from Ann Arbor to Knoxville.ExpandLaunch map view
  • Distance: 485.5 mi
  • Duration: 3h 40m

What companies run services between Ann Arbor, MI, USA and Knoxville, TN, USA?

You can take a bus from Ann Arbor Amtrak Station to Knoxville via Toledo Bus Stop, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 28h 51m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound