There are 7 ways to get from Ann Arbor to Louisville by bus, plane, bus (Greyhound, Flixbus, Amtrak), train, car, or bus (Amtrak, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Detroit, fly to Louisville International Airport
best- Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus
- Fly from Detroit (DTW) to Louisville International Airport (SDF)plane DTW - SDF
4h 24m$138–920Bus
cheapest- Take the bus from Ann Arbor to Detroit Bus Stationbus
- Take the bus from Detroit to Indianapolisbus
- Take the bus from Indianapolis Union Station to Louisville, KYbus
10h 5m$56–126Train, bus (Amtrak)
- Take the train from Ann Arbor Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Indianapolistrain
- Take the bus from Indianapolis Union Station to Louisville, KYbus
13h 7m$256–420Drive 346.1 mi
- Drive from Ann Arbor to Louisvillecar 346.1 mi
5h 52m$64–92Bus to Detroit, fly to Blue Grass Airport, drive
- Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus
- Fly from Detroit (DTW) to Blue Grass Airport (LEX)plane DTW - LEX
- Drive from Lexington-Airport-LEX to Louisvillecar
4h 22m$90–506Drive to Capital Region International Airport, fly to Louisville International Airport
- Drive from Ann Arbor to Lansing-Airport-LANcar
- Fly from Capital Region International Airport (LAN) to Louisville International Airport (SDF)plane LAN - SDF
6h 26m$109–671Bus via Toledo
- Take the bus from Ann Arbor Amtrak Station to Toledobus
- Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus
- Take the bus from Indianapolis Union Station to Louisville, KYbus
10h 25m
Ann Arbor to Louisville by bus
Comparing Your Travel Options
The cheapest way to get from Ann Arbor to Louisville is to drive which costs $60 - $95 and takes 5h 52m.
The fastest way to get from Ann Arbor to Louisville is to bus and fly and drive which takes 4h 22m and costs $90 - $550.
No, there is no direct bus from Ann Arbor to Louisville. However, there are services departing from Ann Arbor and arriving at Louisville, KY via Detroit and Indianapolis Union Station. The journey, including transfers, takes approximately 10h 5m.
The distance between Ann Arbor and Louisville is 342 miles. The road distance is 348.2 miles.
The best way to get from Ann Arbor to Louisville without a car is to bus which takes 10h 5m and costs $55 - $130.
It takes approximately 4h 24m to get from Ann Arbor to Louisville, including transfers.
Ann Arbor to Louisville bus services, operated by Greyhound USA, depart from Ann Arbor station.
Ann Arbor to Louisville bus services, operated by Greyhound USA, arrive at Detroit Bus Station.
Yes, the driving distance between Ann Arbor to Louisville is 348 miles. It takes approximately 5h 52m to drive from Ann Arbor to Louisville.
Book your Ann Arbor to Louisville bus tickets online with Omio.
What companies run services between Ann Arbor, MI, USA and Louisville, KY, USA?
You can take a bus from Ann Arbor to Louisville, KY via Detroit and Indianapolis Union Station in around 10h 5m.
- Website
- delta.com
Flights from Detroit to Louisville International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $130–900
Flights from Detroit to Blue Grass Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $70–470
Flights from Capital Region International Airport to Louisville International Airport via Detroit
- Ave. Duration
- 5h 59m
- When
- Every day
- Estimated price
- $95–650
- Website
- aa.com
Flights from Capital Region International Airport to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 5h 34m
- When
- Every day
- Estimated price
- $100–650
Flights from Capital Region International Airport to Louisville International Airport via Reagan Washington
- Ave. Duration
- 5h 38m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $160–800
- Website
- southwest.com
Flights from Detroit to Louisville International Airport via Nashville
- Ave. Duration
- 3h 35m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $180–1,000
Flights from Capital Region International Airport to Louisville International Airport via Orlando
- Ave. Duration
- 6h 23m
- When
- Saturday
- Estimated price
- $350–1,900
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Ann Arbor Amtrak Station to Chicago Union Station
- Ave. Duration
- 4h 18m
- Frequency
- 3 times a day
- Estimated price
- $130–210
- Website
- Amtrak
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $100–170
- Website
- Amtrak
- Phone
- +1 517-333-0400
- [email protected]
- Website
- Michigan Flyer
Bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airport
- Ave. Duration
- 40 min
- Frequency
- Hourly
- Estimated price
- $7–15
- Website
- Michigan Flyer
- Child 2-16
- $7–9
- Adult
- $10–15
Bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airport
- Ave. Duration
- 40 min
- Frequency
- Hourly
- Estimated price
- $7–15
- Website
- Michigan Flyer
- Child 2-16
- $7–9
- Adult
- $10–15
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Ann Arbor to Detroit Bus Station
- Ave. Duration
- 50 min
- Frequency
- 3 times a day
- Estimated price
- $7–12
- Website
- Greyhound
Bus from Toledo Bus Stop to Indianapolis Union Station
- Ave. Duration
- 4h 20m
- Frequency
- Once daily
- Estimated price
- $40–60
- Website
- Greyhound
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Ann Arbor to Detroit Bus Station
- Ave. Duration
- 45 min
- Frequency
- Once daily
- Estimated price
- $4–35
- Website
- Barons Bus
Bus from Detroit to Indianapolis
- Ave. Duration
- 5h 20m
- Frequency
- Once daily
- Estimated price
- $27–70
- Website
- Barons Bus
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Ann Arbor to Detroit Bus Station
- Ave. Duration
- 45 min
- Frequency
- 5 times a week
- Estimated price
- $6–10
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak Thruway
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Indianapolis Union Station to Louisville, KY
- Ave. Duration
- 1h 55m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Bus from Indianapolis Union Station to Louisville, KY
- Ave. Duration
- 1h 55m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Bus from Indianapolis Union Station to Louisville, KY
- Ave. Duration
- 1h 55m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Ann Arbor Amtrak Station to Toledo
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Website
- Amtrak
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