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How to get fromAnn Arbor to Mayo Clinicby bus, plane, bus (Flixbus), train, car, or bus (Amtrak)

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There are 7 ways to get from Ann Arbor to Mayo Clinic by bus, plane, bus (Flixbus), train, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Rochester

    best
    1. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    2. Fly from Detroit (DTW) to Rochester (RST)plane plane DTW - RST
    6h 40m
    $83–487

  2. Bus

    1. Take the bus from Ann Arbor to Milwaukee Intermodal Stationbus bus FlixBus 2550
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    13h 33m
    $124–190

  3. Train, bus

    1. Take the train from Ann Arbor Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    15h 27m
    $237–470

  4. Drive 586.7 mi

    1. Drive from Ann Arbor to Mayo Cliniccar car 586.7 mi
    9h 44m
    $108–155

  5. Bus, fly to Minneapolis–Saint Paul International Airport

    1. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    2. Fly from Detroit (DTW) to Minneapolis–Saint Paul International Airport (MSP)plane plane DTW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 30m
    $529–1,269

  6. Train, bus via Madison

    1. Take the train from Ann Arbor Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    14h 24m
    $154–290

  7. Bus via Chicago

    1. Take the bus from Ann Arbor Amtrak Station to Chicago Union Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    14h 45m
    $158–246

Ann Arbor to Mayo Clinic by train, bus, and foot

Calendar21Weekly Services
Duration15h 27mAverage Duration
Ticket$237Cheapest Price
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Questions & Answers

Map of how to get from Ann Arbor to Mayo Clinic.ExpandLaunch map view
  • Distance: 514.1 mi
  • Duration: 6h 40m

What companies run services between Ann Arbor, MI, USA and Mayo Clinic, MN, USA?

You can take a bus from Ann Arbor to Mayo Clinic via Milwaukee Intermodal Station, Milwaukee, and Rochester in around 13h 33m.

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