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How to get fromAnn Arbor to St. Louisby bus, plane, train (Amtrak), bus (Amtrak, Flixbus), car, or bus (Amtrak, Greyhound)

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There are 6 ways to get from Ann Arbor to St. Louis by bus, plane, train (Amtrak), bus (Amtrak, Flixbus), car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Detroit, fly

    best
    1. Take the bus from Ann Arbor- Blake Transit Ctr., MI to Detroit Metro Airportbus bus
    2. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    4h
    $460–970

  2. Drive 503.6 mi

    cheapest
    1. Drive from Ann Arbor to St. Louiscar car 503.6 mi
    8h 31m
    $92–133

  3. Train (Amtrak)

    1. Take the train from Ann Arbor Amtrak Station to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    10h 4m
    $170–349

  4. Bus via Chicago

    1. Take the bus from Ann Arbor Amtrak Station to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    11h 43m
    $136–204

  5. Drive to Capital Region International Airport, fly

    1. Drive from Ann Arbor to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Lambert–St. Louis International Airport (STL)plane plane LAN - STL
    5h 16m
    $116–671

  6. Bus

    1. Take the bus from Ann Arbor Amtrak Station to Toledobus bus
    2. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    12h 25m
    $104–192

Ann Arbor to St. Louis by train (Amtrak)

Calendar21Weekly Trains
Duration10h 4mAverage Duration
Ticket$170Cheapest Price
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Questions & Answers

Map of how to get from Ann Arbor to St. Louis.ExpandLaunch map view
  • Distance: 482.2 mi
  • Duration: 4h

What companies run services between Ann Arbor, MI, USA and St. Louis, MO, USA?

You can take a train from Ann Arbor Amtrak Station to St. Louis via Chicago Union Station in around 10h 4m. Alternatively, you can take a bus from Ann Arbor Amtrak Station to St Louis Bus Station via Chicago Union Station and Chicago Bus Station in around 11h 43m.

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