There are 8 ways to get from Annapolis to Knoxville by bus, plane, train, car, subway, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Ronald Reagan Washington National Airport, fly to Mcghee Tyson Airport
best- Take the bus from Annapolis to Washington Union Stationbus
- Fly from Ronald Reagan Washington National Airport (DCA) to Mcghee Tyson Airport (TYS)plane DCA - TYS
4h 9m$253–1,284Drive 505.7 mi
cheapest- Drive from Annapolis to Knoxvillecar 505.7 mi
8h 59m$93–134Train, bus
- Take the train from Baltimore Penn Station to Ny Moynihan Train Hall At Penn Stationtrain Acela
- Take the bus from New York, NY to Knoxville, TNbus Ny
18h 18m$187–282Bus, subway to Washington Dulles International Airport, fly to Mcghee Tyson Airport
- Take the bus from Annapolis to Washington Union Stationbus
- Take the subway from Metro Center, Blue/Orange/Silver Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway
- Fly from Washington Dulles International Airport (IAD) to Mcghee Tyson Airport (TYS)plane IAD - TYS
4h 36m$183–833Line 70 bus to Baltimore-Washington International Airport, fly to Mcghee Tyson Airport
- Take the bus from COLLEGE AVE & BLADEN ST eb to Cromwell Light Rail Station Bay 1bus
- Fly from Baltimore-Washington International Airport (BWI) to Mcghee Tyson Airport (TYS)plane BWI - TYS
4h 34m$201–980Bus to Ronald Reagan Washington National Airport, fly to Asheville Regional Airport, drive
- Take the bus from Annapolis to Washington Union Stationbus
- Fly from Ronald Reagan Washington National Airport (DCA) to Asheville Regional Airport (AVL)plane DCA - AVL
- Drive from Asheville-Airport-AVL to Knoxvillecar
5h 55m$110–599Bus via Farragut
- Take the bus from West St & Church Cir to Patapsco Light Rail Station Bay 3bus 70
- Take the bus from Baltimore, MD to New York -152 East Broadwaybus
- Take the bus from New York to Knoxvillebus Nyc
20h 27m$216–306Bus
- Take the bus from West St & Church Cir to Patapsco Light Rail Station Bay 3bus 70
- Take the bus from Baltimore Downtown Bus Station to New York City Chinatownbus
- Take the bus from New York, NY to Knoxville, TNbus Ny
23h 27m$138–174
Ronald Reagan Washington National Airport (DCA) to Mcghee Tyson Airport (TYS) flights
Comparing Your Travel Options
The cheapest way to get from Annapolis to Knoxville is to drive which costs $90 - $140 and takes 8h 59m.
The fastest way to get from Annapolis to Knoxville is to bus and fly which takes 4h 9m and costs $250 - $1,300.
No, there is no direct bus from Annapolis to Knoxville. However, there are services departing from West St & Church Cir and arriving at Knoxville via Patapsco Light Rail Station Bay 2, Pratt St & Light St, Baltimore, MD and New York. The journey, including transfers, takes approximately 20h 27m.
The distance between Annapolis and Knoxville is 488 miles. The road distance is 508.6 miles.
The best way to get from Annapolis to Knoxville without a car is to train and bus which takes 18h 18m and costs $180 - $290.
It takes approximately 4h 9m to get from Annapolis to Knoxville, including transfers.
Annapolis to Knoxville bus services, operated by Maryland Transit, depart from West St & Church Cir station.
Annapolis to Knoxville bus services, operated by Maryland Transit, arrive at Patapsco Light Rail Station Bay 3.
Yes, the driving distance between Annapolis to Knoxville is 509 miles. It takes approximately 8h 59m to drive from Annapolis to Knoxville.
Book your Annapolis to Knoxville bus tickets online with Omio.
What companies run services between Annapolis, MD, USA and Knoxville, TN, USA?
You can take a bus from West St & Church Cir to Knoxville via Patapsco Light Rail Station Bay 2, CALVERT ST between PRATT ST & LOMBARD ST nb, Pratt St & Light St, O'Donnell St Cutoff & Travel Center, Baltimore, MD, New York -152 East Broadway, New York, and Knoxville in around 20h 27m.
- Website
- aa.com
Flights from Ronald Reagan Washington National Airport to Mcghee Tyson Airport
- Ave. Duration
- 1h 45m
- When
- Every day
- Estimated price
- $190–1,200
Flights from Ronald Reagan Washington National Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- $200–1,300
Flights from Ronald Reagan Washington National Airport to Asheville Regional Airport
- Ave. Duration
- 1h 37m
- When
- Every day
- Estimated price
- $80–550
Flights from Ronald Reagan Washington National Airport to Asheville Regional Airport via Charlotte
- Ave. Duration
- 3h 42m
- When
- Every day
- Estimated price
- $85–550
Rome2Rio's guide to Amtrak Acela
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Baltimore Penn Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 2h 28m
- Frequency
- Every 2 hours
- Estimated price
- $40–700
- Schedules at
- Amtrak Acela
- Website
- Amtrak
- Business Class
- $40–480
- First Class
- $180–700
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Annapolis to Washington Union Station
- Ave. Duration
- 45 min
- Frequency
- Once daily
- Estimated price
- $4–7
- Schedules at
- Flixbus USA
Bus from Annapolis to Washington Union Station
- Ave. Duration
- 45 min
- Frequency
- Once daily
- Estimated price
- $4–7
- Schedules at
- Flixbus USA
Bus from Annapolis to Washington Union Station
- Ave. Duration
- 45 min
- Frequency
- Once daily
- Estimated price
- $4–7
- Schedules at
- Flixbus USA
Bus from Baltimore Downtown Bus Station to New York City Chinatown
- Ave. Duration
- 3h 40m
- Frequency
- 5 times a day
- Estimated price
- $35–55
- Schedules at
- Flixbus USA
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Booking & Getting There
There are 326+ hotels available in Knoxville.

