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How to get fromAntofagasta to Cuscoby plane, bus, or car

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There are 6 ways to get from Antofagasta to Cusco by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Antofagasta Airport (ANF) to Alejandro Velasco Astete International Airport (CUZ)plane plane ANF - CUZ
    5h 17m
    $242–416

  2. Bus #3

    cheapest
    1. Take the bus from Terminal de Buses Cardenal Carlos Oviedo Cavada to Terminal Rodoviario de Aricabus bus
    2. Take the bus from Terminal Internacional to Tacnabus bus
    3. Take the bus from Tacna Bus Station to Cusco Bus Stationbus bus
    28h 54m
    $46–106

  3. Bus via Tocopilla

    1. Take the bus from Terminal de Buses Cardenal Carlos Oviedo Cavada to Agencia Tocopilla - Turbusbus bus
    2. Take the bus from Terminal de Buses Tocopilla to Terminal Rodoviario de Aricabus bus
    3. Take the bus from Terminal Internacional to Tacnabus bus
    4. Take the bus from Tacna to Moqueguabus bus
    5. Take the bus from Moquegua to Arequipabus bus
    6. Take the bus from Arequipa to Cuscobus bus
    20h 19m

  4. Drive  1,559.4 km

    1. Drive from Antofagasta to Cuscocar car 1,559.4 km
    23h 11m
    $235–339

  5. Bus

    1. Take the bus from Terminal de Buses Cardenal Carlos Oviedo Cavada to Terminal Rodoviario de Aricabus bus
    2. Take the bus from Terminal Internacional to Tacnabus bus
    3. Take the bus from Tacna to Moqueguabus bus
    4. Take the bus from Moquegua to Arequipabus bus
    5. Take the bus from Arequipa to Cuscobus bus
    22h 16m

  6. Bus #2

    1. Take the bus from Antofagasta to Baquedanobus bus
    2. Take the bus from Baquedano to Terminal Rodoviario de Aricabus bus
    3. Take the bus from Terminal Internacional to Tacnabus bus
    4. Take the bus from Tacna to Arequipabus bus
    5. Take the bus from Arequipa to Cuscobus bus
    28h 26m

Antofagasta Airport (ANF) to Alejandro Velasco Astete International Airport (CUZ) flights

Calendar8Weekly Planes
Duration7h 52mAverage Duration
Ticket$210Cheapest Price
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Comparing Your Travel Options

Map of how to get from Antofagasta to Cusco.ExpandLaunch map view
  • Distance: 1,139 km
  • Duration: 5h 17m

What companies run services between Antofagasta, Chile and Cusco, Peru?

LATAM Chile and Sky Airline fly from Antofagasta Airport (ANF) to Alejandro Velasco Astete International Airport (CUZ) once daily. Alternatively, you can take a bus from Terminal de Buses Cardenal Carlos Oviedo Cavada to Cusco via Agencia Tocopilla - Turbus, Terminal de Buses Tocopilla, Terminal Rodoviario de Arica, Terminal Internacional, Tacna, Moquegua, and Arequipa in around 20h 19m.

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