There are 4 ways to get from Assisi to Isernia by bus, train (Trenitalia), car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Assisi - Piazza San Pietro to Roma, Autostazione Tiburtinabus
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
6h 20m€31–50Bus, train
cheapest- Take the bus from Assisi - S.M. Angeli - fermata Hotel Antonelli to Cassinobus
- Take the train from Cassino to Iserniatrain Re
8h 2m€30–44Train (Trenitalia)
- Take the train from Assisi to Roma Terminitrain 4735 / ...
- Take the train from Roma Termini to Iserniatrain Re
6h 53m€42–82Drive 286.2 km
- Drive from Assisi to Iserniacar 286.2 km
4h 13m€45–65
Assisi to Isernia by bus
Questions & Answers
The cheapest way to get from Assisi to Isernia is to bus and train which costs €29 - €45 and takes 8h 2m.
The fastest way to get from Assisi to Isernia is to drive which takes 4h 13m and costs €45 - €65.
No, there is no direct bus from Assisi to Isernia. However, there are services departing from Assisi - Piazza San Pietro and arriving at Isernia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 20m.
No, there is no direct train from Assisi to Isernia. However, there are services departing from Assisi and arriving at Isernia via Roma Termini. The journey, including transfers, takes approximately 6h 53m.
The distance between Assisi and Isernia is 371 km. The road distance is 286.2 km.
The best way to get from Assisi to Isernia without a car is to bus which takes 6h 20m and costs €30 - €50.
It takes approximately 6h 20m to get from Assisi to Isernia, including transfers.
Assisi to Isernia bus services, operated by Sulga Autolinee, depart from Assisi - Piazza San Pietro station.
Assisi to Isernia train services, operated by Trenitalia, depart from Assisi station.
The best way to get from Assisi to Isernia is to bus which takes 6h 20m and costs €30 - €50. Alternatively, you can train, which costs €40 - €85 and takes 6h 53m.
What companies run services between Assisi, Italy and Isernia, Italy?
You can take a bus from Assisi - Piazza San Pietro to Isernia via Roma, Autostazione Tiburtina in around 6h 20m. Alternatively, you can take a bus from P.za Matteotti Assisi to Isernia via Assisi, Assisi, and Roma Termini in around 6h 53m.
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Assisi to Roma Termini
- Ave. Duration
- 2h 42m
- Frequency
- Hourly
- Estimated price
- €20–35
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 16m
- Frequency
- Every 3 hours
- Estimated price
- €23–40
- Website
- https://www.trenitalia.com/en.html
Train from Cassino to Isernia
- Ave. Duration
- 48 min
- Frequency
- Every 3 hours
- Estimated price
- €6–11
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Assisi to Roma Termini
- Ave. Duration
- 1h 57m
- Frequency
- Twice daily
- Estimated price
- €17–40
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 075 5009641
- [email protected]
- Website
- sulga.it
Bus from Assisi - Piazza San Pietro to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 10m
- Frequency
- 6 times a week
- Estimated price
- €23–26
- Schedules at
- sulga.it
- 2nd Class
- €23–26
- Phone
- +39 0874 64744
- [email protected]
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- https://www.flixbus.fr
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- €14–24
- Website
- https://www.flixbus.co.uk
- Phone
- +39 089 233 899
- [email protected]
- Website
- autolineecurcio.it
Bus from Assisi - S.M. Angeli - fermata Hotel Antonelli to Cassino
- Ave. Duration
- 4h 20m
- Frequency
- Once daily
- Estimated price
- €21–30
- Website
- https://www.autolineecurcio.it/
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More Questions & Answers
Assisi to Isernia bus services, operated by Sulga Autolinee, arrive at Roma, Autostazione Tiburtina station.
Assisi to Isernia train services, operated by Trenitalia, arrive at Roma Termini station.
Yes, the driving distance between Assisi to Isernia is 286 km. It takes approximately 4h 13m to drive from Assisi to Isernia.
Book your Assisi to Isernia bus tickets online with Omio.
There are 478+ hotels available in Isernia.