There are 8 ways to get from Avignon to Karlsruhe by train (TGV), bus, car, train, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (TGV)
best- Take the train from Avignon Tgv to Karlsruhe Hbftrain Tgv
6h 1m€160–240Bus
cheapest- Take the bus from Avignon to Karlsruhe central train stationbus FlixBus N1135 / ...
10h 50m€55–110Drive 760.8 km
- Drive from Avignon to Karlsruhecar 760.8 km
7h 32m€122–177Train to Marseille Provence Airport, fly to Strasbourg International Airport, train
- Take the train from Avignon Tgv to Aix En Provence Tgvtrain
- Fly from Marseille Provence Airport (MRS) to Strasbourg International Airport (SXB)plane MRS - SXB
- Take the train from Strasbourg to Karlsruhe Hbftrain
5h 9m€66–340Bus, train
- Take the bus from Avignon - Le Pontet - Le Lac Stop to Mannheim - Bus Stationbus BlaBlaCar Bus
- Take the train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhoftrain 12 / ...
12h 40m€69–153Train to Lyon–Saint Exupéry Airport, fly to Strasbourg International Airport, train
- Take the train from Avignon Tgv to Lyon-Saint Exupery Tgvtrain
- Fly from Lyon–Saint Exupéry Airport (LYS) to Strasbourg International Airport (SXB)plane LYS - SXB
- Take the train from Strasbourg to Karlsruhe Hbftrain
4h 54m€140–416Train to Marseille Provence Airport, fly to Frankfurt, train
- Take the train from Avignon Tgv to Aix En Provence Tgvtrain
- Fly from Marseille Provence Airport (MRS) to Frankfurt (FRA)plane MRS - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhoftrain
6h 38m€116–327Train, train to Nice Côte D'Azur International Airport, fly to Strasbourg International Airport
- Take the train from Avignon Tgv to Marseille St Charlestrain
- Take the train from Marseille-Saint-Charles to Nice-Saint-Augustintrain
- Fly from Nice Côte D'Azur International Airport (NCE) to Strasbourg International Airport (SXB)plane NCE - SXB
- Take the train from Strasbourg to Karlsruhe Hbftrain
8h 23m€117–362
Avignon to Karlsruhe by train (TGV)
Comparing Your Travel Options
The cheapest way to get from Avignon to Karlsruhe is to bus which costs €55 - €110 and takes 10h 50m.
The fastest way to get from Avignon to Karlsruhe is to train and fly which takes 4h 54m and costs €140 - €420.
Yes, there is a direct bus departing from Avignon and arriving at Karlsruhe central train station station. Services depart twice daily, and operate every day. The journey takes approximately 10h 50m.
Yes, there is a direct train departing from Avignon Tgv and arriving at Karlsruhe Hbf. Services depart once daily, and operate every day. The journey takes approximately 6h 1m.
The distance between Avignon and Karlsruhe is 808 km. The road distance is 760.8 km.
The best way to get from Avignon to Karlsruhe without a car is to train which takes 6h 1m and costs €160 - €240.
The train from Avignon Tgv to Karlsruhe Hbf takes 6h 1m including transfers and departs once daily.
Avignon to Karlsruhe bus services, operated by FlixBus, depart from Avignon station.
Avignon to Karlsruhe train services, operated by TGV inOui, depart from Avignon Tgv station.
The best way to get from Avignon to Karlsruhe is to train which takes 6h 1m and costs €160 - €240. Alternatively, you can bus, which costs €55 - €110 and takes 10h 50m.
What companies run services between Avignon, France and Karlsruhe, Germany?
TGV inOui operates a train from Avignon Tgv to Karlsruhe Hbf once daily. Tickets cost €160–240 and the journey takes 6h 1m. Alternatively, FlixBus operates a bus from Avignon to Karlsruhe central train station twice daily. Tickets cost €70–110 and the journey takes 10h 50m. BlaBlaCar Bus also services this route once daily.
- Website
- easyjet.com
Flights from Nice Côte D'Azur International Airport to Strasbourg International Airport
- Ave. Duration
- 1h 21m
- When
- Every day
- Estimated price
- €40–220
- Website
- twinjet.fr
Flights from Marseille Provence Airport to Strasbourg International Airport
- Ave. Duration
- 1h 40m
- When
- Tuesday and Wednesday
- Estimated price
- €700–1,500
Flights from Lyon–Saint Exupéry Airport to Strasbourg International Airport
- Ave. Duration
- 1h 10m
- When
- Monday to Friday
- Estimated price
- €650–1,500
- Website
- volotea.com
Flights from Marseille Provence Airport to Strasbourg International Airport
- Ave. Duration
- 1h 25m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €35–220
Flights from Nice Côte D'Azur International Airport to Strasbourg International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €30–170
- Website
- lufthansa-city.com
Flights from Marseille Provence Airport to Frankfurt
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €45–280
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Avignon Tgv to Karlsruhe Hbf
- Ave. Duration
- 6h 1m
- Frequency
- Once daily
- Estimated price
- €160–240
- Website
- TGV inOui
Train from Avignon Tgv to Aix En Provence Tgv
- Ave. Duration
- 19 min
- Frequency
- Every 30 minutes
- Estimated price
- €14–22
- Website
- TGV inOui
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 50 min
- Frequency
- Every 4 hours
- Estimated price
- €15–24
- Website
- TGV inOui
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 50 min
- Frequency
- Every 4 hours
- Estimated price
- €15–24
- Website
- TGV inOui
Train from Avignon Tgv to Aix En Provence Tgv
- Ave. Duration
- 19 min
- Frequency
- Every 30 minutes
- Estimated price
- €14–22
- Website
- TGV inOui
Train from Avignon Tgv to Marseille St Charles
- Ave. Duration
- 35 min
- Frequency
- Every 30 minutes
- Estimated price
- €18–28
- Website
- TGV inOui
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 50 min
- Frequency
- Every 4 hours
- Estimated price
- €15–24
- Website
- TGV inOui
Rome2Rio's guide to Société Nationale des Chemins de fer Français (SNCF)
Contact DetailsContact Details
- Phone
- +33 1 84 94 36 35
- Website
- Oui.SNCF
Train from Avignon Tgv to Aix En Provence Tgv
- Ave. Duration
- 22 min
- Frequency
- Hourly
- Estimated price
- €13–22
- Website
- Oui.SNCF
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 49 min
- Frequency
- Twice a week
- Estimated price
- €13–23
- Website
- Oui.SNCF
Train from Avignon Tgv to Lyon-Saint Exupery Tgv
- Ave. Duration
- 51 min
- Frequency
- Every 3 hours
- Estimated price
- €35–65
- Website
- Oui.SNCF
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 49 min
- Frequency
- Twice a week
- Estimated price
- €13–23
- Website
- Oui.SNCF
Train from Avignon Tgv to Aix En Provence Tgv
- Ave. Duration
- 22 min
- Frequency
- Hourly
- Estimated price
- €13–22
- Website
- Oui.SNCF
Train from Avignon Tgv to Marseille St Charles
- Ave. Duration
- 42 min
- Frequency
- Hourly
- Estimated price
- €16–28
- Website
- Oui.SNCF
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 49 min
- Frequency
- Twice a week
- Estimated price
- €13–23
- Website
- Oui.SNCF
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Avignon Tgv to Aix En Provence Tgv
- Ave. Duration
- 20 min
- Frequency
- Every 4 hours
- Estimated price
- €8–13
- Website
- Trenitalia
Train from Avignon Tgv to Lyon-Saint Exupery Tgv
- Ave. Duration
- 50 min
- Frequency
- 5 times a day
- Estimated price
- €25–35
- Website
- Trenitalia
Train from Avignon Tgv to Aix En Provence Tgv
- Ave. Duration
- 20 min
- Frequency
- Every 4 hours
- Estimated price
- €8–13
- Website
- Trenitalia
Train from Avignon Tgv to Marseille St Charles
- Ave. Duration
- 35 min
- Frequency
- Every 4 hours
- Estimated price
- €11–16
- Website
- Trenitalia
- Phone
- +34 91 232 03 20
- Website
- Renfe Viajeros
Train from Avignon Tgv to Aix En Provence Tgv
- Ave. Duration
- 19 min
- Frequency
- 4 times a day
- Estimated price
- €9–14
- Website
- Renfe Viajeros
Train from Avignon Tgv to Aix En Provence Tgv
- Ave. Duration
- 19 min
- Frequency
- 4 times a day
- Estimated price
- €9–14
- Website
- Renfe Viajeros
Train from Avignon Tgv to Marseille St Charles
- Ave. Duration
- 37 min
- Frequency
- 4 times a day
- Estimated price
- €11–17
- Website
- Renfe Viajeros
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 41 min
- Frequency
- Every 4 hours
- Estimated price
- €13–30
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 22 min
- Frequency
- Hourly
- Estimated price
- €10–23
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 41 min
- Frequency
- Every 4 hours
- Estimated price
- €13–30
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 8m
- Frequency
- Every 3 hours
- Estimated price
- €22–50
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 41 min
- Frequency
- Every 4 hours
- Estimated price
- €13–30
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 57 min
- Frequency
- Hourly
- Estimated price
- €11–50
- Website
- Deutsche Bahn Regio (DB Regional)
- Phone
- +31 30 751 5155
- Website
- Nederlandse Spoorwegen (NS)
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 28 min
- Frequency
- Twice daily
- Estimated price
- €6–13
- Website
- Nederlandse Spoorwegen (NS)
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 53m
- Frequency
- Twice daily
- Estimated price
- €14–28
- Website
- Nederlandse Spoorwegen (NS)
- Phone
- +49 621 830 1200
- Website
- Süwex
Train from Mannheim, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 6m
- Frequency
- 5 times a week
- Estimated price
- €13–19
- Schedules at
- Süwex
- Phone
- +33 4 13 94 30 50
- Website
- Zou! Lignes Express Régionales
Train from Marseille-Saint-Charles to Nice-Saint-Augustin
- Ave. Duration
- 2h 32m
- Frequency
- Hourly
- Estimated price
- €55–80
- Website
- Zou! Lignes Express Régionales
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Avignon to Karlsruhe central train station
- Ave. Duration
- 10h 50m
- Frequency
- Twice daily
- Estimated price
- €70–110
- Website
- Flixbus
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Avignon to Karlsruhe central train station
- Ave. Duration
- 11h
- Frequency
- Once daily
- Estimated price
- €55–100
- Website
- BlaBlaCar Bus
Bus from Avignon - Le Pontet - Le Lac Stop to Mannheim - Bus Station
- Ave. Duration
- 12h 5m
- Frequency
- Once daily
- Estimated price
- €60–110
- Website
- BlaBlaCar Bus
Want to know more about travelling around Germany
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Want to know more about Flixbus?
Read the travel guide
5 delightfully under-the-radar French towns you need to visit
Read the travel guide
Train travel in France: A guide to SNCF
Read the travel guide
Booking & Getting There
Avignon to Karlsruhe bus services, operated by FlixBus, arrive at Karlsruhe central train station.
Avignon to Karlsruhe train services, operated by TGV inOui, arrive at Karlsruhe Hbf station.
Yes, the driving distance between Avignon to Karlsruhe is 761 km. It takes approximately 7h 32m to drive from Avignon to Karlsruhe.
Book your Avignon to Karlsruhe train tickets online with Omio.
Book your Avignon to Karlsruhe bus tickets online with Omio and FlixBus.
There are 895+ hotels available in Karlsruhe.











































