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How to get fromBaltimore to Florenceby bus (Greyhound, Flixbus), train (Amtrak), car, plane, train, or bus

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There are 11 ways to get from Baltimore to Florence by bus (Greyhound, Flixbus), train (Amtrak), car, plane, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Baltimore Downtown Bus Station to Raleigh Bus Stationbus bus Greyhound US0700 / ...
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    9h 50m
    $66–130

  2. Train (Amtrak)

    1. Take the train from Baltimore Penn Station to Florence Stationtrain train Palmetto / ...
    11h 51m
    $110–260

  3. Drive  437.7 mi

    1. Drive from Baltimore to Florencecar car 437.7 mi
    7h 35m
    $80–116

  4. Fly Baltimore-Washington International Airport to Charleston International Airport, train

    1. Fly from Baltimore-Washington International Airport (BWI) to Charleston International Airport (CHS)plane plane BWI - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    7h 58m
    $451–1,161

  5. Bus, train

    1. Take the bus from Baltimore Downtown Bus Station to Fayetteville Bus Stationbus bus FlixBus N2471 / ...
    2. Take the train from Fayetteville Amtrak Station to Florence Stationtrain train Palmetto / ...
    10h 11m
    $74–135

  6. Fly Baltimore-Washington International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Baltimore-Washington International Airport (BWI) to Charlotte Douglas International Airport (CLT)plane plane BWI - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    8h 24m
    $120–335

  7. Fly Baltimore-Washington International Airport to Myrtle Beach, bus, train

    1. Fly from Baltimore-Washington International Airport (BWI) to Myrtle Beach (MYR)plane plane BWI - MYR
    2. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    8h 59m
    $313–750

  8. Fly Baltimore-Washington International Airport to Raleigh-Durham International Airport, train

    1. Fly from Baltimore-Washington International Airport (BWI) to Raleigh-Durham International Airport (RDU)plane plane BWI - RDU
    2. Take the train from Raleigh Union Station to Selma Stationtrain train
    3. Take the train from Selma Station to Florence Stationtrain train
    9h 32m
    $222–452

  9. Train to Ronald Reagan Washington National Airport, fly to Columbia, bus

    1. Take the train from Baltimore Penn Station to Washington Union Stationtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Columbia (CAE)plane plane DCA - CAE
    3. Take the bus from Columbia, SC to Camdenbus bus
    4. Take the bus from Camden to Florence Bus Stationbus bus
    10h 3m
    $130–1,169

  10. Train to Ronald Reagan Washington National Airport, fly to Myrtle Beach, bus, train

    1. Take the train from Baltimore Penn Station to Washington Union Stationtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Myrtle Beach (MYR)plane plane DCA - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    10h 5m
    $127–1,119

  11. Train to Ronald Reagan Washington National Airport, fly to Raleigh-Durham International Airport, train

    1. Take the train from Baltimore Penn Station to Washington Union Stationtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Raleigh-Durham International Airport (RDU)plane plane DCA - RDU
    3. Take the train from Raleigh Union Station to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    10h 29m
    $596–1,861

Baltimore to Florence by bus

Calendar14Weekly Buses
Duration9h 50mAverage Duration
Ticket$66Cheapest Price
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Questions & Answers

Map of how to get from Baltimore to Florence.ExpandLaunch map view
  • Distance: 448.1 mi
  • Duration: 9h 50m

What companies run services between Baltimore, MD, USA and Florence, SC, USA?

You can take a bus from Baltimore Downtown Bus Station to Florence Bus Station via Raleigh Bus Station in around 9h 50m. Alternatively, Amtrak operates a train from Baltimore Penn Station to Florence Station twice daily. Tickets cost $110–260 and the journey takes 11h 51m.

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