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How to get fromBiloxi to Chicagoby plane, train (Amtrak), bus (Greyhound, Amtrak), car, or bus

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There are 6 ways to get from Biloxi to Chicago by plane, train (Amtrak), bus (Greyhound, Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gulfport-Biloxi Regional Airport to Chicago Midway International Airport

    best
    1. Fly from Gulfport-Biloxi Regional Airport (GPT) to Chicago Midway International Airport (MDW)plane plane GPT - MDW
    5h 34m
    $168–468

  2. Fly Gulfport-Biloxi Regional Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Gulfport-Biloxi Regional Airport (GPT) to Chicago O'Hare International Airport (ORD)plane plane GPT - ORD
    5h 36m
    $103–398

  3. Train (Amtrak)

    1. Take the train from Biloxi, MS to New Orleans, LA - Union Passenger Terminaltrain train Mobile / ...
    2. Take the train from New Orleans Union Passenger Terminal to Chicago Union Stationtrain train City of New Orleans
    22h 38m
    $543–866

  4. Bus

    1. Take the bus from Biloxi Transit Center to Montgomery Intermodal Centerbus bus
    2. Take the bus from Montgomery Intermodal Center to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Chicago Union Stationbus bus
    23h 45m
    $181–280

  5. Drive  899.9 mi

    1. Drive from Biloxi to Chicagocar car 899.9 mi
    14h 55m
    $165–238

  6. Bus to Louis Armstrong New Orleans International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Biloxi Transit Center to New Orleans Bus Stationbus bus
    2. Fly from Louis Armstrong New Orleans International Airport (MSY) to Chicago Midway International Airport (MDW)plane plane MSY - MDW
    6h 58m
    $128–633

Biloxi to Chicago by bus

Calendar7Weekly Buses
Duration23h 45mAverage Duration
Ticket$181Cheapest Price
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Comparing Your Travel Options

Map of how to get from Biloxi to Chicago.ExpandLaunch map view
  • Distance: 813.9 mi
  • Duration: 5h 34m

What companies run services between Biloxi, MS, USA and Chicago, IL, USA?

Delta, American Airlines, and two other airlines fly from Gulfport-Biloxi Regional Airport (GPT) to Chicago Midway International Airport (MDW) 4 times a day. Alternatively, you can take a train from Biloxi, MS to Chicago Union Station via New Orleans Union Passenger Terminal in around 22h 38m.

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